ReviewTransgender health2023
The Effect of Gender-Affirming Hormones on Gender Dysphoria, Quality of Life, and Psychological Functioning in Transgender Individuals: A Systematic Review.
Review in Transgender health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Gender affirming hormone therapy for individuals with gender dysphoria aged <26 years: a systematic review and meta-analysis.Archives of disease in childhood · 2025Pooled it
- Do hormones and surgery improve the health of adults with gender incongruence? A systematic review of patient reported outcomes.ANZ journal of surgery · 2025Pooled it
- Impact of Distinct Antiandrogen Exposures on the Plasma Metabolome in Feminizing Gender-affirming Hormone Therapy.The Journal of clinical endocrinology and metabolism · 2024Trial
- Course of Testosterone Levels and Potential Biochemical Biomarkers of Androgenization with a Conservative Protocol of Androgen Hormone Therapy in Transgender Males.Journal of clinical medicine · 2026Article
- Mental Health, Gender Dysphoria, and Quality of Life in Trans Individuals Following Top Surgery: Protocol for a Prospective Cohort Study.JMIR research protocols · 2026Article
- Impact of Gender-Affirming Care Legislation on Medical Student Plans for Residency.Transgender health · 2026Article
- Review
- Structural and sociodemographic determinants of BREAST-Q outcomes after gender-affirming breast augmentation in transgender women.JPRAS open · 2026Article
- 'I Would Feel Failed By the Medical Community Entirely': Transgender Americans' Calls for Advocacy From Health Professionals in a Care-Restricted World.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Initiation and Maintenance of Low-Dose Transdermal Testosterone in Non-Binary Individuals: A Retrospective Audit.Clinical endocrinology · 2026Article
- Venous Thromboembolism in Transgender and Gender Diverse Individuals on Estrogen-Based Gender-Affirming Hormone Therapy.Journal of clinical medicine · 2026Article
- Determinants of male global health and quality of life in Switzerland: a cross-sectional study using a gender-diverse approach.BMJ open · 2026Article
- An Exploration of the Views and Perspectives of Australian Trans and Gender Diverse Individuals About Transvaginal Ultrasound.Perspectives on sexual and reproductive health · 2026Article
- Heart rate variability in transgender people receiving Gender-Affirming hormone therapy.Endocrine · 2026Article
- A call for greater attention to embodied change in trans health research.International journal of transgender health · 2026Article
- Traditional and individual care pathways in gender-affirming healthcare for transgender and gender-diverse individuals - results from the ENIGI follow-up study.International journal of impotence research · 2026Article
- Mental health problems and social functioning across different treatment stages in Chinese subjects with gender dysphoria in Hong Kong.Frontiers in psychiatry · 2026Article
- Plasma proteome adaptations during feminizing gender-affirming hormone therapy.Nature medicine · 2026Article
- A systematic review of functional neurological disorder in transgender people.International journal of transgender health · 2026Review
- Vocal-Gender Incongruence, wellbeing, and safety: The medical necessity of gender-affirming vocal training.International journal of transgender health · 2026Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gender-affirming hormone therapy (GAHT) is an essential part of gender affirmation for many transgender (including people with binary and nonbinary identities) individuals and although controlled studies are unethical, there remains limited evidence on the impact of GAHT on gender dysphoria, quality of life (QoL), and psychological functioning. Some clinicians and policy makers use the lack of evidence to argue against providing gender-affirming care. The aim of this review is to systematically and critically assess the available literature on the influence of GAHT on improving gender- and body-related dysphoria, psychological well-being, and QoL. Using Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, we searched Ovid MEDLINE
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.