Evidence map›Paper›PMID 36895287›Full record

ArticleOpen forum infectious diseases2023

Morgan Simpson, Terry Bilverstone, Jhansi Leslie, Alexandra Donlan, Md Jashim Uddin, William A Petri, Natasha Marin, Sarah Kuehne, Nigel P Minton, William A Petri

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  3. Comparative Relatedness ofAntibiotics (Basel, Switzerland) · 2025
    Article
  4. Unravelling three-way interactions betweenJournal of medical microbiology · 2025
    Review
  5. Article
  6. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Morgan SimpsonDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.
Terry BilverstoneBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, United Kingdom.
Jhansi LeslieDepartment of Medicine, Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, Virginia, USA.
Alexandra DonlanDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Md Jashim UddinDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.
William A PetriDepartment of Medicine, Division of Infectious Diseases & International Health, University of Virginia, Charlottesville, Virginia, USA.
Natasha MarinBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, United Kingdom.
Sarah KuehneBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, United Kingdom.
Nigel P MintonBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Nottingham, United Kingdom.ORCID https://orcid.org/0000-0002-9277-1261
William A PetriDepartment of Pathology, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USEngineering and Physical Sciences Research Council · GB

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Role of Th17 in Severe and Recurrent C. difficile InfectionR01AI152477 · NIAID · UNIVERSITY OF VIRGINIA · PI PETRI, WILLIAM A, RAMAKRISHNAN, GIRIJA · 2020 to 2025
$7.1M
Role of Type 2 Immunity in Innate Protection from C. difficileR01AI124214 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2016 to 2026
$5.4M
Medical Research Council G0601176NIAID NIH HHS R01 AI124214NIAID NIH HHS R01 AI152477NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

Background: Methods: To determine the contribution of the separate components of CDT during infection, we developed strains of Results: Although expression of CDTb without CDTa did not induce significant disease in a mouse model of Conclusions: Overall, this study demonstrates that the binding component of

Indexed as

binary toxinCDTClostridioides difficilehamster model

Identifiers

PMID36895287
PMCPMC9991586
OpenAlexW4318689647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.