Evidence map›Paper›PMID 36895258›Full record

ArticleFrontiers in immunology2022

ICAMs are dispensable for influenza clearance and anti-viral humoral and cellular immunity.

Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E Silva Castanheira, Sara W Feigelson and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Stav KozlovskiDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Ofer RegevDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Anita SapoznikovDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Marina KiznerDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Hagit AchdoutDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Ekaterina Petrovich-KopitmanLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Jacob ElkahalDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Yoseph AddadiLife Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.
Fernanda Vargas E Silva CastanheiraDepartment of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sara W FeigelsonDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Paul KubesDepartment of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Noam ErezDepartment of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
Natalio GarbiDepartment of Cellular Immunology, Institute of Experimental Immunology Medical Faculty, University of Bonn, Bonn, Germany.
Ronen AlonDepartment of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Weizmann Institute of Science · ILIsrael Institute for Biological Research · ILUniversity of Calgary · CAUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

αLβ2 (LFA-1) mediated interactions with ICAM-1 and ICAM-2 predominate leukocyte-vascular interactions, but their functions in extravascular cell-cell communications is still debated. The roles of these two ligands in leukocyte trafficking, lymphocyte differentiation, and immunity to influenza infections were dissected in the present study. Surprisingly, double ICAM-1 and ICAM-2 knock out mice (herein ICAM-1/2

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanAnimalsAntigens, CDAntiviral AgentsCD8-Positive T-LymphocytesCell Adhesion MoleculesHumansImmunity, CellularIntercellular Adhesion Molecule-1MiceAntigens, CDAntiviral AgentsCell Adhesion MoleculesICAM-2 protein, mouseIntercellular Adhesion Molecule-1endotheliuminflammationintegrinsleukocyte traffickingmemory

Identifiers

PMID36895258
PMCPMC9988921
OpenAlexW4321459319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.