Evidence map›Paper›PMID 36895235›Full record

ArticleSurgical neurology international2023

Two weeks administration of tranexamic acid for acute intracerebral hemorrhage: A hospital-based pilot study.

Hirotaka Inoue, Takayuki Kawano, Yuri Iwasaki, Izumi Imada, Kazuhiro Yamada, Kouzo Tashima, Daisuke Muta, Keizo Yamamoto, Akitake Mukasa

Open access · hybridAbstract read
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In one paragraph

Article in Surgical neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hirotaka InoueDepartment of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Takayuki KawanoDepartment of Neurosurgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
Yuri IwasakiClinical Research Center, Hitoyoshi Medical Center, Hitoyoshi, Japan.
Izumi ImadaNeurosurgery Unit, Hitoyoshi Medical Center, Hitoyoshi, Japan.
Kazuhiro YamadaCommunity Medical Cooperation Office, Hitoyoshi Medical Center, Hitoyoshi, Japan.
Kouzo TashimaDepartment of Neurosurgery, Kumamoto Medical Center, Kumamoto, Japan.
Daisuke MutaDepartment of Neurosurgery, Hitoyoshi Medical Center, Hitoyoshi, Japan.
Keizo YamamotoHealthcare Center, Kumamoto Red Cross Hospital, Kumamoto, Japan.
Akitake MukasaDepartment of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kumamoto University · JPKumamoto Medical Center · JPSaiseikai Fukuoka General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A previous report suggested that functional status does not differ between patients who received tranexamic acid and those who received placebo within the early hours of intracerebral hemorrhage (ICH). Our pilot study tested the hypothesis that 2 weeks administration of tranexamic acid would contribute to functional improvement. Methods: Consecutive patients with ICH were administered 250 mg tranexamic acid 3 times a day continuously for 2 weeks. We also enrolled historical control consecutive patients. We collected clinical data that involved hematoma size, level of consciousness, and Modified Rankin Scale (mRS) scores. Results: Univariate analysis showed that the mRS score on day 90 was better in the administration group ( Conclusion: The study could not show the significant effect of 2 weeks administration of tranexamic acid on functional outcomes of ICH patients after the matching; however, suggested that this treatment is at least safe and feasible. A larger and adequately powered trial is needed.

Indexed as

Antifibrinolytic effectAnti-inflammatory effectIntracerebral hemorrhageKallikrein-Kinin systemTranexamic acid

Identifiers

PMID36895235
PMCPMC9990797
OpenAlexW4321789301

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.