Evidence map›Paper›PMID 36895163›Full record

Trial reportThe Prostate2023

Patient-reported functional outcomes and oncological control after primary focal cryotherapy for clinically significant prostate cancer: A Phase II mandatory biopsy-monitored study.

Yu G Tan, Yan M Law, Nye T Ngo, Li Y Khor, Puay H Tan, Enya H W Ong, John S P Yuen, Henry S S Ho, Jeffrey K L Tuan, Ravindran Kanesvaran and 5 more

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Prostate, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04138914 naactive not recruitingnot on this map

Phase II Trial of Focal Cryotherapy for Prostate Cancer

TypeinterventionalSponsorSingapore General HospitalRan2019 to 2041Enrolled30ConditionsProstate CancerArmsFocal Cryotherapy
NCT06491056 recruitingnot on this map

Prospective Multicenter Asian Observational Study of Oncological and Functional Outcomes After Focal Therapy of Prostate Cancer

Typeobservational_patient_registrySponsorSingapore General HospitalRan2023 to 2048Enrolled500ConditionsProstate CancerArmsFocal Therapy for Prostate Cancer
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Surveillance after Focal Therapy - a Comprehensive Review.Prostate cancer and prostatic diseases · 2025
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yu G TanDepartment of Urology, Singapore General Hospital, Singapore.ORCID 0000-0002-8166-0582
Yan M LawDepartment of Diagnostic Radiology, Singapore General Hospital, Singapore.
Nye T NgoDuke-NUS Medical School, Singapore.
Li Y KhorDuke-NUS Medical School, Singapore.
Puay H TanDuke-NUS Medical School, Singapore.
Enya H W OngDivision of Medical Sciences, National Cancer Center Singapore, Singapore.
John S P YuenDepartment of Urology, Singapore General Hospital, Singapore.
Henry S S HoDepartment of Urology, Singapore General Hospital, Singapore.
Jeffrey K L TuanDuke-NUS Medical School, Singapore.
Ravindran KanesvaranDuke-NUS Medical School, Singapore.
Rajan T GuptaDepartment of Radiology, Duke Cancer Centre, Singapore.
Steven RozenDepartment of Bioinformatics, Duke-NUS Medical School, Singapore.
Melvin L K ChuaDuke-NUS Medical School, Singapore.
Thomas J PolascikDepartment of Urology, Duke Cancer Centre, Singapore.
Kae Jack TayDepartment of Urology, Singapore General Hospital, Singapore.
Singapore General Hospital · SGDuke-NUS Medical School · SGNational Cancer Centre Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe report herein the impact of focal therapy (FT) on multi-domain functional outcomes in a Phase II prospective clinical trial (NCT04138914) in focal cryotherapy for clinically significant prostate cancer (csPCa).

methodsThe primary outcome was the detection of a ≥5 point deterioration in any of the four main expanded prostate index composite (EPIC) functional domains. Pretreatment multiparametric magnetic resonance imaging (mpMRI) and transperineal targeted and systematic saturation biopsy were used to select patients with prostate-specific antigen (PSA)≤20 ng/mL, Gleason grade group (GG) ≤4, mpMRI lesion volume ≤ 3 mL (for a single lesion) or ≤1.5 mL (where two lesions were present). Focal cryotherapy was performed with a minimum 5 mm margin around each target lesion. EPIC scores were obtained at baseline and posttreatment at 1, 3, 6, and 12 months. Mandatory repeat mpMRI and prostate biopsy were performed at 12 months to determine the infield and outfield recurrence.

resultsTwenty-eight patients were recruited. The mean age was 68 years, with PSA of 7.3 ng/mL and PSA density of 0.19 ng/mL

conclusionFT using cryotherapy was associated with a transient deterioration of urinary and sexual function with resolution at 3 months posttreatment and with reasonable early efficacy in well-selected csPCa patients.

Indexed as

Prostate-Specific AntigenProstatic NeoplasmsAgedBiopsyCryotherapyHumansMagnetic Resonance ImagingMaleProspective StudiesProstate-Specific Antigenclinically significant prostate cancercryotherapyfocal therapyfunctional outcomes

Identifiers

PMID36895163
PMCPMC10952298
OpenAlexW4323810667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.