ArticleDiabetology & metabolic syndrome2023
Association of triglyceride-glucose index with atherosclerotic cardiovascular disease and mortality among familial hypercholesterolemia patients.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Relationship between the Systemic Immune-Inflammation Index and Muscle Strength in Patients with Chronic Kidney Disease: A Cross-Sectional Study of Data from NHANES 2011-2014.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Evaluation of the Relationship Between Albuminuria and Triglyceride Glucose Index in Patients with Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Triglyceride-glucose index as a marker in cardiovascular diseases; a bibliometric study and visual analysis.Annals of medicine and surgery (2012) · 2025Review
- Joint association of TyG index and LDL-C with all-cause and cardiovascular mortality among patients with cardio-renal-metabolic disease.Scientific reports · 2025Article
- The associations of physical activity patterns and the triglyceride-glucose index in US adults: a secondary data analysis of NHANES (2007-2018).Scientific reports · 2025Article
- Article
- Emergency risk stratification using the TyG index: a multi-center cohort study on nonlinear association with 28-day mortality among critically ill patients transferred from the ED to the ICU.Frontiers in medicine · 2025Article
- Machine learning for predicting in-hospital mortality in elderly patients with heart failure combined with hypertension: a multicenter retrospective study.Cardiovascular diabetology · 2024Article
- The triglyceride-glucose index: a predictor of mortality risk among myocardial infarction survivors.Scientific reports · 2024Article
- Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population.Cardiovascular diabetology · 2024Article
- Association of prognostic nutritional index with mortalities in American adult cancer survivors: A cohort study based on NHANES, 1999-2018.Food science & nutrition · 2024Article
- Oxidative stress mediates the association between triglyceride-glucose index and risk of cardiovascular and all-cause mortality in metabolic syndrome: evidence from a prospective cohort study.Frontiers in endocrinology · 2024Article
- Value of the triglyceride-glucose index and related parameters in heart failure patients.Frontiers in cardiovascular medicine · 2024Review
- Association between TyG index and risk of carotid atherosclerosis in NAFLD patients: a retrospective cohort study.Frontiers in endocrinology · 2024Article
- Associations between nine dietary minerals intake and all-cause mortality in individuals with atherosclerotic cardiovascular disease.Frontiers in nutrition · 2024Article
- Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study.BMC public health · 2023Article
- Association of Dietary Inflammation Index andMediators of inflammation · 2023Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundFamilial hypercholesterolemia (FH) is an inherited metabolic disorder with a high level of low-density lipoprotein cholesterol and the worse prognosis. The triglyceride-glucose (TyG) index, an emerging tool to reflect insulin resistance (IR), is positively associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) in healthy individuals, but the value of TyG index has never been evaluated in FH patients. This study aimed to determine the association between the TyG index and glucose metabolic indicators, insulin resistance (IR) status, the risk of ASCVD and mortality among FH patients.
methodsData from National Health and Nutrition Examination Survey (NHANES) 1999-2018 were utilized. 941 FH individuals with TyG index information were included and categorized into three groups: < 8.5, 8.5-9.0, and > 9.0. Spearman correlation analysis was used to test the association of TyG index and various established glucose metabolism-related indicators. Logistic and Cox regression analysis were used to assess the association of TyG index with ASCVD and mortality. The possible nonlinear relationships between TyG index and the all-cause or cardiovascular death were further evaluated on a continuous scale with restricted cubic spline (RCS) curves.
resultsTyG index was positively associated with fasting glucose, HbA1c, fasting insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) index (all p < 0.001). The risk of ASCVD increased by 74% with every 1 unit increase of TyG index (95%CI: 1.15-2.63, p = 0.01). During the median 114-month follow-up, 151 all-cause death and 57 cardiovascular death were recorded. Strong U/J-shaped relations were observed according to the RCS results (p = 0.0083 and 0.0046 for all-cause and cardiovascular death). A higher TyG index was independently associated with both all-cause death and cardiovascular death. Results remained similar among FH patients with IR (HOMA-IR ≥ 2.69). Moreover, addition of TyG index showed helpful discrimination of both survival from all-cause death and cardiovascular death (p < 0.05).
conclusionTyG index was applicable to reflect glucose metabolism status in FH adults, and a high TyG index was an independent risk factor of both ASCVD and mortality.
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