SynthesisActa neurologica Belgica2023
Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY).
Synthesis in Acta neurologica Belgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- A stereotactic laser interstitial thermal therapy strategy to flank dense calcifications within epileptogenic lesions: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Pediatric low-grade epilepsy-associated tumors (LEATS): neuroimaging review and genetics update.Pediatric radiology · 2026Review
- From a Polymorphous Low-Grade Neuroepithelial Tumor to a Glioblastoma in an Adult Patient with FGFR3-TACC3 Fusion: A Case Report and Literature Review of the Molecular Profile.Current oncology (Toronto, Ont.) · 2026Review
- Polymorphous low-grade neuroepithelial tumor of the young: a case report.Frontiers in oncology · 2026Article
- Article
- A rare tumor with unique features: polymorphous low-grade neuroepithelial tumor of the young with third ventricular location and TP53 mutation. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Imaging features of polymorphous low-grade neuroepithelial tumors of the young: a case series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Polymorphous low-grade neuroepithelial tumor of the young: case report and literature review.International journal of clinical and experimental pathology · 2025Article
- Polymorphous low-grade neuroepithelial tumor of the young.Surgical neurology international · 2025Article
- Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.Neuropathology and applied neurobiology · 2024Article
- MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations.Brain tumor pathology · 2024Article
- Pediatric-type diffuse low-grade gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Radiomics and artificial intelligence applications in pediatric brain tumors.World journal of pediatrics : WJP · 2024Review
- Expanding the Imaging Spectrum of Polymorphous Low-Grade Neuroepithelial Tumor of the Young in Children.AJNR. American journal of neuroradiology · 2024Article
- Advances in diffuse glial tumors diagnosis.Arquivos de neuro-psiquiatria · 2023Review
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a low-grade epilepsy-associated tumor recently introduced in WHO 2021 classification. Since it has been recognized as an independent nosological entity, PLNTY has been mainly studied from a genetic and molecular perspective, not recognizing unique characteristic clinical and radiological features.
methodsA systematic literature research has been conducted aiming to identify all relevant studies about the radiological, clinical and surgical features of PLNTY. We described a representative case of a 45-year-old man treated with awake-surgery with confirmed diagnosis of PLNTY, reporting the radiological and surgical characteristics through imaging and intra-operative video. We performed a statistical meta-analysis attempting to assess the presence of relationships between surgical and radiologic tumor characteristics and clinical outcome and type of surgery.
resultsA total of 16 studies were included in the systematic review. The final cohort was composed of 51 patients. Extent of resection (EOR) and outcome are not significantly associated with the different genetic profiling (p = 1), the presence of cystic intralesional component, calcification (p = 0.85), contrast-enhancing and lesion boundaries (p = 0.82). No significant correlation there is between EOR and remission or better control of epilepsy-related symptoms (p = 0.38). The contrast enhancement in the tumor is significantly associated with recurrence or poor control of epileptic symptoms (p = 0.07).
conclusionsIn PLNTYs, contrast enhancement seems to impact prognosis, recurrence, and seizure control much more than radiological features, genetic features and type of resection of the tumor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.