Evidence map›Paper›PMID 36894723›Full record

ArticleNature chemical biology2023

Elucidating dynamic anaerobe metabolism with HRMAS

Aidan Pavao, Brintha Girinathan, Johann Peltier, Pamela Altamirano Silva, Bruno Dupuy, Isabella H Muti, Craig Malloy, Leo L Cheng, Lynn Bry

Open access · hybridAbstract read
In one paragraph

Article in Nature chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Live Metabolomics with NMR.Analytical chemistry · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Aidan PavaoMassachusetts Host-Microbiome Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7516-6633
Brintha GirinathanMassachusetts Host-Microbiome Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Johann PeltierLaboratoire Pathogenèse des Bactéries Anaérobies, F-75015, Institut Pasteur, Université Paris-Cité, UMR-CNRS 6047, Paris, France.
Pamela Altamirano SilvaCentre for Investigations in Tropical Diseases, Faculty of Microbiology, University of Costa Rica, San José, Costa Rica.
Bruno DupuyLaboratoire Pathogenèse des Bactéries Anaérobies, F-75015, Institut Pasteur, Université Paris-Cité, UMR-CNRS 6047, Paris, France.ORCID http://orcid.org/0000-0001-7176-8453
Isabella H MutiDepartments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Craig MalloyDepartment of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-5077-0642
Leo L ChengDepartments of Radiology and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. lcheng@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-5975-5406
Lynn BryMassachusetts Host-Microbiome Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. lbry@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-8792-8527
Brigham and Women's Hospital · USCentre National de la Recherche Scientifique · FRHarvard University · USThe University of Texas Southwestern Medical Center · USUniversidad de Costa Rica · CR

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuliR01AG070257 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE G, XIE, ZHONGCONG · 2021 to 2025
$3.9M
Commensal control of C. difficile virulenceR01AI153605 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRY, LYNN · 2021 to 2025
$3.4M
INVESTIGATING TYPE VI SECRETION IN ACINETOBACTER BAUMANNII AND ITS INTERPLAY WITH ANTIBIOTIC RESISTAR01AI125363 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2016 to 2020
$1.9M
Upgrade of Console for 600 MHz MR SpectrometerS10OD023406 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2017 to 2017
$600k
Identification of prostate cancer aggressiveness using hyperpolarized polyamine metabolic ratesR21CA243255 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2019 to 2020
$436k
NMR-resolved dynamics of C. difficile metabolismR03AI174158 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRY, LYNN · 2023 to 2024
$179k
NCI NIH HHS R21 CA243255NIAID NIH HHS R01 AI125363NIAID NIH HHS R01 AI153605NIAID NIH HHS R03 AI174158NIA NIH HHS R01 AG070257NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P30 DK034854NIDDK NIH HHS P30 DK056338NIH HHS S10 OD023406
6 · The paper itself

Abstract

Anaerobic microbial metabolism drives critical functions within global ecosystems, host-microbiota interactions, and industrial applications, yet remains ill-defined. Here we advance a versatile approach to elaborate cellular metabolism in obligate anaerobes using the pathogen Clostridioides difficile, an amino acid and carbohydrate-fermenting Clostridia. High-resolution magic angle spinning nuclear magnetic resonance (NMR) spectroscopy of C. difficile, grown with fermentable

Indexed as

Clostridioides difficileAlanineAmino AcidsAnaerobiosisEcosystemMagnetic Resonance SpectroscopyAlanineAmino Acids

Identifiers

PMID36894723
PMCPMC10154198
OpenAlexW4323669941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.