Evidence map›Paper›PMID 36894684›Full record

ArticleNature methods2023

Rapid biomechanical imaging at low irradiation level via dual line-scanning Brillouin microscopy.

Jitao Zhang, Milos Nikolic, Kandice Tanner, Giuliano Scarcelli

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature methods, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  5. Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Mechanical Evolution of Metastatic Cancer Cells in 3D Microenvironment.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jitao Zhang *Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA. zhang4@wayne.edu.ORCID http://orcid.org/0000-0002-6240-0371
Milos Nikolic *Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-1206-1797
Kandice TannerLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Giuliano ScarcelliFischell Department of Bioengineering, University of Maryland, College Park, MD, USA. scarc@umd.edu.ORCID http://orcid.org/0000-0002-1736-077X
National Institutes of Health · USUniversity of Maryland, College Park · USWayne State University · US

Funding

The Role of Coherent Rotation in Adult Tissue RemodelingZIABC011433 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TANNER, KANDICE · 2012 to 2025
$7.2M
Mechano-chemical regulation of the microenvironmental niche in melanomaZIABC011524 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TANNER, KANDICE · 2013 to 2025
$6.2M
Cornea biomechanical analysis with Brillouin microscopyR01EY028666 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI James Bradley Randleman, Giuliano Scarcelli · 2018 to 2026
$4.1M
Biomechanics of Neural Tube Development using Brillouin-OCT MultimodalityR01HD095520 · NICHD · UNIVERSITY OF HOUSTON · PI FINNELL, RICHARD H., LARIN, KIRILL V · 2018 to 2022
$3.3M
Optically mapping tissue biomechanics during neural tube closureK25HD097288 · NICHD · WAYNE STATE UNIVERSITY · PI ZHANG, JITAO · 2019 to 2023
$562k
Stimulated Brillouin Flow Cytometry for biomechanical assessment of metastatic potentialR21CA258008 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI KONSTANTOPOULOS, KONSTANTINOS, MARTIN, STUART S · 2022 to 2023
$543k
NCI NIH HHS R21 CA258008NEI NIH HHS R01 EY028666NICHD NIH HHS K25 HD097288NICHD NIH HHS R01 HD095520
6 · The paper itself

Abstract

Brillouin microscopy is a technique for mechanical characterization of biological material without contact at high three-dimensional resolution. Here, we introduce dual line-scanning Brillouin microscopy (dLSBM), which improves acquisition speed and reduces irradiation dose by more than one order of magnitude with selective illumination and single-shot analysis of hundreds of points along the incident beam axis. Using tumor spheroids, we demonstrate the ability to capture the sample response to rapid mechanical perturbations as well as the spatially resolved evolution of the mechanical properties in growing spheroids.

Indexed as

LightingNeoplasmsHumansMicroscopy, Confocal

Identifiers

PMID36894684
PMCPMC10363327
OpenAlexW4323669993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.