Evidence map›Paper›PMID 36894655›Full record

ArticleNature neuroscience2023

Developmental trajectory of transmission speed in the human brain.

Dorien van Blooijs, Max A van den Boom, Jaap F van der Aar, Geertjan M Huiskamp, Giulio Castegnaro, Matteo Demuru, Willemiek J E M Zweiphenning, Pieter van Eijsden, Kai J Miller, Frans S S Leijten and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
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  6. Article
  7. Article
  8. Hierarchical Flows of Human Cortical Activity.bioRxiv : the preprint server for biology · 2026
    Article
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  11. Review
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  15. Article
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  18. Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dorien van Blooijs *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7998-414X
Max A van den Boom *Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5481-1659
Jaap F van der AarDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0001-6387-5144
Geertjan M HuiskampDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Giulio CastegnaroDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Matteo DemuruDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Willemiek J E M ZweiphenningDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Pieter van EijsdenDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Kai J MillerDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6687-6422
Frans S S LeijtenDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-2603-3364
Dora HermesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. hermes.dora@mayo.edu.ORCID http://orcid.org/0000-0002-8683-8909
University Medical Center Utrecht · NLMayo Clinic in Arizona · USMayo Clinic · US

Funding

CRCNS: Processing speed in the human connectome across the lifespanR01MH122258 · NIMH · MAYO CLINIC ROCHESTER · PI HERMES, DORA · 2019 to 2023
$1.8M
NIMH NIH HHS R01 MH122258
6 · The paper itself

Abstract

The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect the speed of neuronal signaling is not well described. In 74 subjects, we measured the latency of cortico-cortical evoked responses across association and U-fibers and calculated their corresponding transmission speeds. Decreases in conduction delays until at least 30 years show that the speed of neuronal communication develops well into adulthood.

Indexed as

ConnectomeWhite MatterAdolescentBrainChildHumansMiddle AgedNeuronsSignal Transduction

Identifiers

PMID36894655
PMCPMC10076215
OpenAlexW4323669803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.