Evidence map›Paper›PMID 36894653›Full record

ArticleNPJ digital medicine2023

Machine learning for accurate estimation of fetal gestational age based on ultrasound images.

Lok Hin Lee, Elizabeth Bradburn, Rachel Craik, Mohammad Yaqub, Shane A Norris, Leila Cheikh Ismail, Eric O Ohuma, Fernando C Barros, Ann Lambert, Maria Carvalho and 12 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Real-time gestational-age estimation at 11-13 weeks using artificial intelligence on non-targeted ultrasound sweeps.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
  3. Article
  4. The FemTech revolution: Unlocking the potential of new technology for optimizing pregnancy outcomes in low- and middle-income countries and remote areas.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  5. Emerging applications of artificial intelligence for obstetric ultrasound: A scoping review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
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  8. Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lok Hin Lee *Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Elizabeth Bradburn *Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5165-6865
Rachel CraikNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7885-0775
Mohammad YaqubIntelligent Ultrasound Ltd, Hodge House, Cardiff, CF10 1DY, UK.
Shane A NorrisSouth African Medical Research Council Developmental Pathways for Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa.
Leila Cheikh IsmailCollege of Health Sciences, University of Sharjah, University City, United Arab Emirates.
Eric O OhumaNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Fernando C BarrosPrograma de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, Brazil.
Ann LambertNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Maria CarvalhoFaculty of Health Sciences, Aga Khan University, Nairobi, Kenya.
Yasmin A JafferDepartment of Family & Community Health, Ministry of Health, Muscat, Oman.
Michael GravettDepartments of Obstetrics and Gynecology and of Global Health, University of Washington, Seattle, WA, USA.
Manorama PurwarNagpur INTERGROWTH-21st Research Centre, Ketkar Hospital, Nagpur, India.
Qingqing WuSchool of Public Health, Peking University, Beijing, China.
Enrico BertinoDipartimento di Scienze Pediatriche e dell' Adolescenza, Struttura Complessa Direzione Universitaria Neonatologia, Università di Torino, Torino, Italy.
Shama MunimDepartment of Obstetrics & Gynaecology, Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.
Aung Myat MinShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand.
Zulfiqar BhuttaDepartment of Obstetrics & Gynaecology, Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.
Jose VillarNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Stephen H KennedyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
J Alison Noble *Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3060-3772
Aris T Papageorghiou *Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK. aris.papageorghiou@wrh.ox.ac.uk.ORCID http://orcid.org/0000-0001-8143-2232

Funding

Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) INV-000368
6 · The paper itself

Abstract

Accurate estimation of gestational age is an essential component of good obstetric care and informs clinical decision-making throughout pregnancy. As the date of the last menstrual period is often unknown or uncertain, ultrasound measurement of fetal size is currently the best method for estimating gestational age. The calculation assumes an average fetal size at each gestational age. The method is accurate in the first trimester, but less so in the second and third trimesters as growth deviates from the average and variation in fetal size increases. Consequently, fetal ultrasound late in pregnancy has a wide margin of error of at least ±2 weeks' gestation. Here, we utilise state-of-the-art machine learning methods to estimate gestational age using only image analysis of standard ultrasound planes, without any measurement information. The machine learning model is based on ultrasound images from two independent datasets: one for training and internal validation, and another for external validation. During validation, the model was blinded to the ground truth of gestational age (based on a reliable last menstrual period date and confirmatory first-trimester fetal crown rump length). We show that this approach compensates for increases in size variation and is even accurate in cases of intrauterine growth restriction. Our best machine-learning based model estimates gestational age with a mean absolute error of 3.0 (95% CI, 2.9-3.2) and 4.3 (95% CI, 4.1-4.5) days in the second and third trimesters, respectively, which outperforms current ultrasound-based clinical biometry at these gestational ages. Our method for dating the pregnancy in the second and third trimesters is, therefore, more accurate than published methods.

Identifiers

PMID36894653
PMCPMC9998590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.