Evidence map›Paper›PMID 36894635›Full record

ArticleBone marrow transplantation2023

Benchmarking of survival outcomes following Haematopoietic Stem Cell Transplantation (HSCT): an update of the ongoing project of the European Society for Blood and Marrow Transplantation (EBMT) and Joint Accreditation Committee of ISCT and EBMT (JACIE).

Riccardo Saccardi, Hein Putter, Dirk-Jan Eikema, María Paula Busto, Eoin McGrath, Bas Middelkoop, Gillian Adams, Marina Atlija, Francis Ayuketang Ayuk, Helen Baldomero and 38 more

Abstract read
In one paragraph

Article in Bone marrow transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  5. Dependence and clinical fragility in hematopoietic stem cell transplant and CAR-T therapy: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Riccardo SaccardiCellular Therapy and Transfusion Medicine Unit, Careggi University Hospital, Florence, Italy. riccardo.saccardi@aouc.unifi.it.
Hein PutterDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-5395-1422
Dirk-Jan EikemaEBMT Statistical Unit Leiden, Leiden, the Netherlands.
María Paula BustoEBMT Registry, Leiden, the Netherlands.
Eoin McGrathICCBBA, Barcelona, Spain.ORCID 0000-0002-1956-037X
Bas MiddelkoopEBMT Registry, Leiden, the Netherlands.
Gillian AdamsEBMT Executive Office, Barcelona, Spain.
Marina AtlijaEBMT Registry, Leiden, the Netherlands.
Francis Ayuketang AyukDepartment of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany.
Helen BaldomeroCentre for Hematology and Oncology, University Hospital Basel, Basel, Switzerland.ORCID 0000-0002-6554-483X
Yves BeguinDepartment of Hematology, CHU of Liège and University of Liège, Liège, Belgium.
Rafael de la CámaraInfectious Diseases Working Party (IDWP), Barcelona, Spain.
Ángel CedilloGrupo Español de Trasplantes Hematopoyéticos y Terapia Celular (GETH-TC), Madrid, Spain.
Anna María Sureda BalariHematology Department, Institut Català d'Oncologia-Hospitalet, Barcelona, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
Christian ChabannonCentre de Thérapie Cellulaire, Institut Paoli-Calmettes Comprehensive Cancer Centre, Aix-Marseille Université School of Medicine & Inserm CBT-1409, Centre d'Investigations Cliniques en Biothérapies, Marseille, France.ORCID 0000-0002-3755-4889
Selim CorbaciogluDepartment of Paediatric Oncology, Haematology and Stem Cell Transplantation, University Children's Hospital Regensburg, Regensburg, Germany.
Harry DolstraLaboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Rafael F DuarteHospital Universitario Puerta de Hierro Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain.
Rémy DulerySorbonne Université, INSERM UMRs938, Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, AP-HP, Paris, France.ORCID 0000-0002-5024-1713
Raffaella GrecoBlood and Marrow Transplant (BMT) Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Andreu GusiEBMT Executive Office, Barcelona, Spain.
Nada HamadDepartment of Haematology, St Vincent's Hospital Sydney, Sydney, NSW, Australia.ORCID 0000-0001-7929-1450
Michelle KenyonKenyon, M, Department of Haematology, King's College Hospital NHS Foundation Trust, London, United Kingdom.
Nicolaus KrögerDepartment of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany.ORCID 0000-0001-5103-9966
Myriam LabopinSorbonne University, Department of Hematology, Hôpital Saint Antoine, and INSERM UMRs 938, Paris, France.
Julia LeeBritish Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT) Data Registry, London, United Kingdom.
Per LjungmanDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Lynn MansonEdinburgh & SE Scotland Clinical Transfusion Centre Patient Services and the Edinburgh & SE Scotland Clinical Apheresis Unit, Edinburgh, United Kingdom.
Florence MensilAgence de la Biomédecine, Saint-Denis, France.
Noel MilpiedCentre Hospitalier Universitaire (CHU) Bordeaux, Service d'Hematologie et Therapie Cellulaire, Bordeaux, France.ORCID 0000-0002-5177-014X
Mohamad MohtySorbonne University, Hôpital Saint Antoine (AP-HP), and INSERM UMRs 938, Paris, France.ORCID 0000-0002-7264-808X
Elena OldaniItalian National BMT Registry (GITMO), Bergamo, Italy.
Kim OrchardUniversity Hospital Southampton NHS, London, United Kingdom.
Jakob PasswegHematology division, Basel University Hospital, Basel, Switzerland.
Rachel PearceBritish Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT) Data Registry, London, United Kingdom.
Régis Peffault de LatourBMT unit Paris Cité University, French reference center for aplastic anaemia and PNH, French rare network for rare immunological and haematological disorders (MaRIH), Severe aplastic anaemia working party of the European blood and marrow transplantation group (SAAWP EBMT) Saint-Louis Hospital, Paris, France.
Hélène A PoirelBelgian Transplant Registry, Belgian Cancer Registry, Brussels, Belgium.ORCID 0000-0002-0712-5127
Tuula RintalaKing's College Hospital NHS Foundation Trust, London, United Kingdom.
J Douglas RizzoCIBMTR, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-1474-1152
Annalisa RuggeriHematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Carla Sanchez-MartinezJACIE, EBMT Executive Office, Barcelona, Spain.
Fermin Sanchez-GuijoCIC-University of Salamanca, IBSAL-University Hospital of Salamanca, Salamanca, Spain.ORCID 0000-0002-7076-7739
Isabel Sánchez-OrtegaEBMT Executive Office, Barcelona, Spain.
Marie TrnkováCzech registry, Prague, Czech Republic.
David Valcárcel FerreirasGrupo Español de Trasplantes Hematopoyéticos y Terapia Celular (GETH-TC), Madrid, Spain.
Leonie WilcoxAustralasian Bone Marrow Transplant Recipient Registry (ABMTRR), Darlinghurst, NSW, Australia.
Liesbeth C de WreedeDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-7667-9369
John A SnowdenDepartment of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.ORCID 0000-0001-6819-3476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From 2016 EBMT and JACIE developed an international risk-adapted benchmarking program of haematopoietic stem cell transplant (HSCT) outcome to provide individual EBMT Centers with a means of quality-assuring the HSCT process and meeting FACT-JACIE accreditation requirements relating to 1-year survival outcomes. Informed by previous experience from Europe, North America and Australasia, the Clinical Outcomes Group (COG) established criteria for patient and Center selection, and a set of key clinical variables within a dedicated statistical model adapted to the capabilities of the EBMT Registry. The first phase of the project was launched in 2019 to test the acceptability of the benchmarking model through assessment of Centers' performance for 1-year data completeness and survival outcomes of autologous and allogeneic HSCT covering 2013-2016. A second phase was delivered in July 2021 covering 2015-2019 and including survival outcomes. Reports of individual Center performance were shared directly with local principal investigators and their responses were assimilated. The experience thus far has supported the feasibility, acceptability and reliability of the system as well as identifying its limitations. We provide a summary of experience and learning so far in this 'work in progress', as well as highlighting future challenges of delivering a modern, robust, data-complete, risk-adapted benchmarking program across new EBMT Registry systems.

Indexed as

BenchmarkingHematopoietic Stem Cell TransplantationAccreditationBone MarrowEuropeHumansReproducibility of Results

Identifiers

PMID36894635
PMCPMC9995719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.