ArticleScientific reports2023
Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Pooled it
- Dose-response relationship between serum uric acid and albuminuria showing a linear trend specific to the hyperuricemic range.Clinical and experimental nephrology · 2026Article
- CKDs at the Crossroads: From Failures to Future Therapies.Kidney international reports · 2025Review
- Uncovering the Link Between Kynurenic Acid Pathway and Kidney Failure.Kidney international reports · 2025Article
- Association between urate-lowering therapy and kidney failure in patients with chronic kidney disease.Journal of nephrology · 2025Article
- The Uricosuric Effect of SGLT2 Inhibitors Is Maintained in the Long Term in Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus.Journal of clinical medicine · 2024Article
- Nonlinearity association between hyperuricemia and all-cause mortality in patients with chronic kidney disease.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the shape of the relationship between longitudinal uric acid (UA) and the hazard of kidney failure and death in chronic kidney disease (CKD) patients, and attempted to identify thresholds associated with increased hazards. We included CKD stage 3-5 patients from the CKD-REIN cohort with one serum UA measurement at cohort entry. We used cause-specific multivariate Cox models including a spline function of current values of UA (cUA), estimated from a separate linear mixed model. We followed 2781 patients (66% men, median age, 69 years) for a median of 3.2 years with a median of five longitudinal UA measures per patient. The hazard of kidney failure increased with increasing cUA, with a plateau between 6 and 10 mg/dl and a sharp increase above 11 mg/dl. The hazard of death had a U-shape relationship with cUA, with a hazard twice higher for 3 or 11 mg/dl, compared to 5 mg/dl. In CKD patients, our results indicate that UA above 10 mg/dl is a strong risk marker for kidney failure and death and that low UA levels below 5 mg/dl are associated with death before kidney failure.
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Registered trials
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