ArticleScientific reports2023
Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03458910 (Why Does Heart Rate Variability Matter for Emotion Regulation), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Why Does Heart Rate Variability Matter for Emotion Regulation
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review.The Journal of physiology · 2026Pooled it
- Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Testing effects of paced breathing on plasma Aβ and brain perivascular spaces.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2026Trial
- A Randomized Clinical Trial Reveals Effects of Mindfulness and Slow Breathing on Plasma Amyloid Beta Levels.Psychophysiology · 2025Trial
- "Brain-IT": Exergame training with biofeedback breathing in neurocognitive disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management.Journal of Alzheimer's disease : JAD · 2026Review
- Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers.Journal of Alzheimer's disease : JAD · 2026Article
- Neurophysiological mechanisms of breathing-based well-being practices: a narrative review for clinical application.Frontiers in psychiatry · 2026Review
- Human cerebrospinal fluid net flow enhanced by respiration during the awake state.Nature communications · 2025Article
- Personalized cognitive enhancement for older adults: An aging-friendly closed-loop human-machine interface framework.Ageing research reviews · 2025Review
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training.bioRxiv : the preprint server for biology · 2025Article
- Early detection of Alzheimer's disease using the MEMORIES mnemonic.Chronic diseases and translational medicine · 2025Review
- Heart rate variability biofeedback in a global study of the most common coherence frequencies and the impact of emotional states.Scientific reports · 2025Article
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Effects of Heart Rhythm Meditation on Vagal Tone and Well-being: A Mixed Methods Research Study.Applied psychophysiology and biofeedback · 2024Article
- Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults.Alzheimer's research & therapy · 2024Article
- Article
- Predicting cognitive scores from wearable-based digital physiological features using machine learning: data from a clinical trial in mild cognitive impairment.BMC medicine · 2024Article
- Putting the usability of wearable technology in forensic psychiatry to the test: a randomized crossover trial.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Slow paced breathing via heart rate variability (HRV) biofeedback stimulates vagus-nerve pathways that counter noradrenergic stress and arousal pathways that can influence production and clearance of Alzheimer's disease (AD)-related proteins. Thus, we examined whether HRV biofeedback intervention affects plasma Αβ40, Αβ42, total tau (tTau), and phosphorylated tau-181 (pTau-181) levels. We randomized healthy adults (N = 108) to use slow-paced breathing with HRV biofeedback to increase heart rate oscillations (Osc+) or to use personalized strategies with HRV biofeedback to decrease heart rate oscillations (Osc-). They practiced 20-40 min daily. Four weeks of practicing the Osc+ and Osc- conditions produced large effect size differences in change in plasma Aβ40 and Aβ42 levels. The Osc+ condition decreased plasma Αβ while the Osc- condition increased Αβ. Decreases in Αβ were associated with decreases in gene transcription indicators of β-adrenergic signaling, linking effects to the noradrenergic system. There were also opposing effects of the Osc+ and Osc- interventions on tTau for younger adults and pTau-181 for older adults. These results provide novel data supporting a causal role of autonomic activity in modulating plasma AD-related biomarkers.Trial registration: NCT03458910 (ClinicalTrials.gov); first posted on 03/08/2018.
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