Evidence map›Paper›PMID 36894321›Full record

ArticleeNeuro2023

Glycolytic System in Axons Supplement Decreased ATP Levels after Axotomy of the Peripheral Nerve.

Tomofumi Takenaka, Yuichiro Ohnishi, Masamichi Yamamoto, Daiki Setoyama, Haruhiko Kishima

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Tomofumi TakenakaDepartment of neurosurgery, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.ORCID 0000-0001-7005-327X
Yuichiro OhnishiDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan ohnishinsurg@gmail.com hkishima@nsurg.med.osaka-u.ac.jp.
Masamichi YamamotoDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Osaka, 564-8565, Japan.
Daiki SetoyamaDepartment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Haruhiko KishimaDepartment of neurosurgery, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan ohnishinsurg@gmail.com hkishima@nsurg.med.osaka-u.ac.jp.ORCID 0000-0002-9041-2337
Kyushu University · JPNational Cerebral and Cardiovascular Center · JPOsaka City University · JPOsaka Neurological Institute · JPOsaka Ohtani University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wallerian degeneration (WD) occurs in the early stages of numerous neurologic disorders, and clarifying WD pathology is crucial for the advancement of neurologic therapies. ATP is acknowledged as one of the key pathologic substances in WD. The ATP-related pathologic pathways that regulate WD have been defined. The elevation of ATP levels in axon contributes to delay WD and protects axons. However, ATP is necessary for the active processes to proceed WD, given that WD is stringently managed by auto-destruction programs. But little is known about the bioenergetics during WD. In this study, we made sciatic nerve transection models for

Indexed as

AxonsWallerian DegenerationAdenosine TriphosphateAnimalsAxotomyMiceNerve RegenerationRatsSciatic NerveAdenosine TriphosphateATPglycolytic systemin vivo imagingmitochondriaWallerian degeneration

Identifiers

PMID36894321
PMCPMC10035771
OpenAlexW4323657059

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read64
identifiers read5
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.