ArticleNeuron2023
Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662174 (VENTURE-PHH), which is not on this map. Cited by 44 papers.
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0cells of the map it votes in
44citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07662174 phase1 / phase2not yet recruitingnot on this mapstarted 2027, after this paper: background citation
VENTURE-PHH: Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage
Who cites it
44 citing papers in PubMed, 64 citations in OpenAlex.
- Elevated TNF-α in cerebrospinal fluid as a potential inflammatory marker in post-hemorrhagic hydrocephalus: a prospective study.Neurosurgical review · 2025Trial
- Ablation of the choroid plexus attenuates hydrocephalus-induced parenchymal edema with moderate reduction of postnatal hippocampal neurogenesis.Fluids and barriers of the CNS · 2026Article
- Pathological mutation L241P in Kir7.1 channel inhibits its activity in the choroid plexus epithelium and decreases cerebrospinal fluid KJournal of physiology and biochemistry · 2026Article
- Article
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus.Fluids and barriers of the CNS · 2026Article
- Serial failure of the brain clearance continuum in Alzheimer's disease: mechanisms and therapeutic perspectives.Journal of neurology · 2026Review
- Acupuncture improves neurological function in ICH rats via suppression of WNK-SPAK-NKCC1 signaling activation.Journal of molecular histology · 2026Article
- Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice.Cell biochemistry and function · 2026Article
- [A novel strategy for the diagnosis and treatment of complex hydrocephalus in children: A staged surgical management protocol].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Adeno-associated viruses (AAVs) induce dose-dependent neonatal ventriculomegaly following intracerebroventricular administration.bioRxiv : the preprint server for biology · 2025Article
- Intraventricular iron causes severe hydrocephalus - a model of severe neonatal hydrocephalus.Fluids and barriers of the CNS · 2025Article
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage.Acta neuropathologica communications · 2025Article
- The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.Molecular neurobiology · 2025Review
- Molecular hallmarks of hydrocephalus.Science translational medicine · 2025Review
- Growth Factors and the Choroid Plexus: Their Role in Posthemorrhagic Hydrocephalus.Biomedicines · 2025Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
- Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage.BMC neurology · 2025Article
- Research priorities for non-invasive therapies to improve hydrocephalus outcomes.Fluids and barriers of the CNS · 2025Review
Corrections and comments
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Authors and funding
27 authors at 6 institutions in 1 country.
Cameron SadeghDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Huixin XuDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jason SutinFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Benoit FatouDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Suhasini GuptaDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Aja PraganaDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Milo TaylorDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard College, Harvard University, Cambridge, MA 02138, USA.
Peter N KaluginDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Miriam E ZawadzkiDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
Osama AlturkistaniCellular Imaging Core, Boston Children's Hospital, Boston, MA 02115, USA.
Frederick B ShipleyDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.
Neil DaniDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Ryann M FameDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Zainab WurieDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Pratik TalatiDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Riana L SchleicherDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Eric M KleinCarney Institute for Brain Science, Brown University, Providence, RI 02912, USA.
Yong ZhangPulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
Michael J HoltzmanPulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
Christopher I MooreCarney Institute for Brain Science, Brown University, Providence, RI 02912, USA.
Pei-Yi LinFetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Aman B PatelDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Benjamin C WarfDepartment of Neurosurgery, Boston Children's Hospital, Boston, MA 02115, USA.
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Hanno SteenDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA.
Mark L AndermannGraduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Maria K LehtinenDepartment of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA. Electronic address: maria.lehtinen@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · USMassachusetts General Hospital · USWashington University in St. Louis · USAllen Institute for Brain Science · USBrown University · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MViral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3MTRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MMOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MDefining and Controlling Airway DiseaseR35HL145242 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2019 to 2025
$6.6MNeuromodulatory mechanisms underlying vagus nerve stimulation therapy for Alzheimer's diseaseDP1AT010971 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2019 to 2023
$6.6MHigh-throughput proteomics using submicroliter amounts of plasma for comprehensive assessment of the immune statusU24AI152179 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI STEEN, HANNO · 2020 to 2024
$6.3MControl of neural stem cells by the nascent cerebrospinal fluidR01NS088566 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA · 2014 to 2024
$5.5MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2MA Functional and Selective Toolkit for Choroid Plexus NetworksRF1DA048790 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA, MOORE, CHRISTOPHER I · 2019 to 2019
$3.3MNCCIH NIH HHS DP1 AT010971NEI NIH HHS P30 EY012196NHLBI NIH HHS R35 HL145242NHLBI NIH HHS T32 HL007901NHLBI NIH HHS T32 HL110852NIAID NIH HHS R01 AI130591NIAID NIH HHS U24 AI152179NICHD NIH HHS P50 HD105351NICHD NIH HHS R00 HD083512NICHD NIH HHS R01 HD096693NICHD NIH HHS U54 HD090255NIDA NIH HHS RF1 DA048790NIDDK NIH HHS F30 DK131642NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM008313NIGMS NIH HHS T32 GM144273NINDS NIH HHS F31 NS115369NINDS NIH HHS R01 NS088566NINDS NIH HHS R01 NS129823
Abstract
Post-hemorrhagic hydrocephalus (PHH) refers to a life-threatening accumulation of cerebrospinal fluid (CSF) that occurs following intraventricular hemorrhage (IVH). An incomplete understanding of this variably progressive condition has hampered the development of new therapies beyond serial neurosurgical interventions. Here, we show a key role for the bidirectional Na-K-Cl cotransporter, NKCC1, in the choroid plexus (ChP) to mitigate PHH. Mimicking IVH with intraventricular blood led to increased CSF [K
Indexed as
Choroid PlexusHydrocephalusCerebral HemorrhageHumansadeno-associated virusCerebrospinal fluidchoroid plexusepithelial cellsgene therapyhydrocephalusintraventricular hemorrhageNKCC1ventricles
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NCT07662174ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.