ArticleMagnetic resonance in medicine2023
Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study.Fluids and barriers of the CNS · 2023Trial
- Hierarchical Bayesian Modelling Improves Microstructural Parameter Mapping in Diffusion and Exchange MRI Data.NMR in biomedicine · 2026Article
- Measuring blood-brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post-mortem approaches.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Article
- On the structural and practical identifiability of multi-echo BBB-ASL tracer kinetic models.Magnetic resonance in medicine · 2026Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- MRI detects blood-brain barrier alterations in a rat model of Alzheimer's disease and lung infection.Npj imaging · 2025Article
- Research Progress on Glioma Microenvironment and Invasiveness Utilizing Advanced Multi-Parametric Quantitative MRI.Cancers · 2024Review
- Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?NMR in biomedicine · 2024Article
- Water exchange across the blood-brain barrier and epilepsy: Review on pathophysiology and neuroimaging.Epilepsia open · 2024Review
- Blood-brain barrier water exchange measurements using contrast-enhanced ASL.NMR in biomedicine · 2023Article
- Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease.Medicina (Kaunas, Lithuania) · 2023Review
- Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects.Magnetic resonance in medicine · 2023Article
- Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.Fluids and barriers of the CNS · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate potential modeling paradigms and the impact of relaxation time effects on human blood-brain barrier (BBB) water exchange measurements using FEXI (BBB-FEXI), and to quantify the accuracy, precision, and repeatability of BBB-FEXI exchange rate estimates at 3
methodsThree modeling paradigms were evaluated: (i) the apparent exchange rate (AXR) model; (ii) a two-compartment model (
resultsThe assumption of infinite relaxation times yielded exchange rate errors in simulations up to 42%/14% in the AXR/
conclusionCompartmental modelling of BBB-FEXI signals can provide accurate and repeatable measurements of BBB water exchange; however, relaxation time and partial volume effects may cause model-dependent biases.
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