Evidence map›Paper›PMID 36892945›Full record

ArticleAIDS care2023

Depression and PrEP uptake, interruption, and adherence among young women in Uganda.

Yasaman Zia, Lydia Nambala, Randy M Stalter, Timothy R Muwonge, Timothy Ssebuliba, Agnes Nakyanzi, Olivia Nampewo, Jade Boyer, Susan Morrison, Rogers Nsubuga and 7 more

Open access · hybridAbstract read
In one paragraph

Article in AIDS care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Yasaman ZiaDepartments of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6049-3706
Lydia NambalaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Randy M StalterDepartments of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2619-7721
Timothy R MuwongeInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Timothy SsebulibaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Agnes NakyanziInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Olivia NampewoInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Jade BoyerGlobal Health, University of Washington, Seattle, WA, USA.
Susan MorrisonGlobal Health, University of Washington, Seattle, WA, USA.
Rogers NsubugaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Monica BagayaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Robert NyanziInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Flavia MatovuMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.ORCID 0000-0002-0046-4353
Michael YinDepartment of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9346-9056
Christina WyattDepartment of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC, USA.
Andrew MujugiraGlobal Health, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6646-6733
Renee HeffronDepartments of Epidemiology, University of Washington, Seattle, WA, USA.
Infectious Diseases Institute · UGUniversity of Washington · USColumbia University Irving Medical Center · USDuke University · USMUJHU Research Collaboration · UGSacramento City College · US

Funding

VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Impact of Concurrent Initiation of DMPA Contraception and Tenofovir PrEP on Bone Loss in Young WomenR01HD089843 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2017 to 2021
$3.9M
Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention productsK24MH123371 · NIMH · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2021 to 2025
$749k
NIAID NIH HHS T32 AI007140NICHD NIH HHS R01 HD089843NIMH NIH HHS K24 MH123371
6 · The paper itself

Abstract

Depression is a common cause of morbidity globally and can impact adherence to medications, posing challenges to medication-based HIV prevention. The objectives of this work are to describe the frequency of depression symptoms in a cohort of 499 young women in Kampala, Uganda and to determine the association of depression symptoms with use of HIV pre-exposure prophylaxis (PrEP). Mild or greater depression, assessed by the patient health questionnaire (PHQ-9), was experienced by 34% of participants at enrollment. Participants with mild depression symptoms tended to uptake PrEP, request PrEP refills, and adhere to PrEP with similar frequency to women with no/minimal signs of depression. These findings highlight opportunities to leverage existing HIV prevention programs to identify women who may benefit from mental health services and may not otherwise be screened.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisDepressionFemaleHumansMedication AdherenceUgandaAnti-HIV AgentsDepressionHIV preventionMental healthPrEP

Identifiers

PMID36892945
PMCPMC11293432
OpenAlexW4323653835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.