Evidence map›Paper›PMID 36892667›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Multicentric development and evaluation of

François Lucia, Vincent Bourbonne, Clémence Pleyers, Pierre-François Dupré, Omar Miranda, Dimitris Visvikis, Olivier Pradier, Ronan Abgral, Augustin Mervoyer, Jean-Marc Classe and 10 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. PET-CT radiomics and artificial intelligence for predicting lymph node metastasis in cervical cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  12. Artificial Intelligence in Obstetric and Gynecological MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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  16. [Diagnostics (Basel, Switzerland) · 2024
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  18. Clinical application ofJapanese journal of radiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

François LuciaRadiation Oncology Department, University Hospital, Brest, France. francois.lucia@chu-brest.fr.ORCID 0000-0001-7286-1350
Vincent BourbonneRadiation Oncology Department, University Hospital, Brest, France.
Clémence PleyersDepartment of Radiotherapy Oncology, University Hospital of Liège, Liège, Belgium.
Pierre-François DupréDepartment of Gynecology and Surgery, University Hospital, Brest, France.
Omar MirandaRadiation Oncology Department, University Hospital, Brest, France.
Dimitris VisvikisLaTIM, INSERM, UMR 1101, Univ Brest, Brest, France.
Olivier PradierRadiation Oncology Department, University Hospital, Brest, France.
Ronan AbgralNuclear Medicine Department, University Hospital, Brest, France.
Augustin MervoyerDepartment of Radiation Oncology, Institut de Cancérologie de l'Ouest Centre René Gauducheau, Saint Herblain, France.
Jean-Marc ClasseDepartment of Surgical Oncology, Institut de Cancérologie de l'Ouest Centre René Gauducheau, Saint Herblain, France.
Caroline RousseauUniversité de Nantes, CNRS, Inserm, CRCINA, F-44000, Nantes, France.
Wim VosRadiomics SA, Liège, Belgium.
Johanne HermesseDepartment of Radiotherapy Oncology, University Hospital of Liège, Liège, Belgium.
Christine GennigensDepartment of Medical Oncology, University Hospital of Liège, Liège, Belgium.
Marjolein De CuypereDepartment of Gynecology, University Hospital of Liège, Liège, Belgium.
Frédéric KridelkaDepartment of Gynecology, University Hospital of Liège, Liège, Belgium.
Ulrike SchickRadiation Oncology Department, University Hospital, Brest, France.
Mathieu HattLaTIM, INSERM, UMR 1101, Univ Brest, Brest, France.
Roland HustinxDivision of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Liège, Belgium.
Pierre LovinfosseDivision of Nuclear Medicine and Oncological Imaging, University Hospital of Liège, Liège, Belgium.
Inserm · FRUniversity of Liège · BECentre Hospitalier Régional Universitaire de Brest · FRInstitut de Cancérologie de l'Ouest · FRCentre National de la Recherche Scientifique · FRUniversité de Bretagne Occidentale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop machine learning models to predict para-aortic lymph node (PALN) involvement in patients with locally advanced cervical cancer (LACC) before chemoradiotherapy (CRT) using

methodsWe retrospectively collected 178 patients (60% for training and 40% for testing) in 2 centers and 61 patients corresponding to 2 further external testing cohorts with LACC between 2010 to 2022 and who had undergone pretreatment analog or digital

resultsIn the training set (n = 102), the clinical model achieved a good prediction of the risk of PALN involvement with a C-statistic of 0.80 (95% CI 0.71, 0.87). However, it performed in the testing (n = 76) and external testing sets (n = 30 and n = 31) with C-statistics of only 0.57 to 0.67 (95% CI 0.36, 0.83). The ComBat-radiomic (GLDZM_HISDE_PET_FBN64 and Shape_maxDiameter2D3_PET_FBW0.25) and ComBat-combined (FIGO 2018 and same radiomics features) models achieved very high predictive ability in the training set and both models kept the same performance in the testing sets, with C-statistics from 0.88 to 0.96 (95% CI 0.76, 1.00) and 0.85 to 0.92 (95% CI 0.75, 0.99), respectively.

conclusionsRadiomic features extracted from pre-CRT analog and digital

Indexed as

Positron Emission Tomography Computed TomographyUterine Cervical NeoplasmsFemaleFluorodeoxyglucose F18HumansLymph NodesMagnetic Resonance ImagingRetrospective StudiesFluorodeoxyglucose F1818F-FDG PET/CTCervical cancerDigital 18F-FDG PET/CTMRIPara-aortic lymph nodeRadiomics

Identifiers

PMID36892667
OpenAlexW4323653592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.