Evidence map›Paper›PMID 36892613›Full record

ArticleNeuroradiology2023

Altered static and dynamic indices of intrinsic brain activity in patients with subcortical ischemic vascular disease: a resting-state functional magnetic resonance imaging analysis.

Ziyang Song, Zhiwei Wu, Zheping Zhou, Mengmeng Feng, Yuanqing Liu, Mengya Ma, Yue Chang, Hanqi Xing, Lan Shen, Yueju Wang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ziyang SongDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhiwei WuDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zheping ZhouDepartment of Geratology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Mengmeng FengDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yuanqing LiuDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Mengya MaDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yue ChangDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hanqi XingDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Lan ShenDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China. shenlan19760910@163.com.
Yueju WangDepartment of Geratology, The First Affiliated Hospital of Soochow University, Suzhou, China. wangyueju@suda.edu.cn.
Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China. huizi198208@126.com.ORCID http://orcid.org/0000-0001-5024-559X
Soochow University · CNSuzhou University of Science and Technology · CN

Funding

National Natural Science Foundation of China grant number 81971573Suzhou Gusu Medical Youth Talent grant number GSWS2020019
6 · The paper itself

Abstract

purposeTo explore the static and dynamic characteristics of intrinsic brain activity (IBA) in subcortical ischemic vascular disease (SIVD) patients with or without cognitive impairment.

methodsIn total, 90 participants were recruited, including 32 SIVD patients with cognitive impairment (SIVD-CI, N = 32), 26 SIVD patients with no cognitive impairment (SIVD-NCI, N = 26), and 32 healthy controls (HC, N = 32) matched for age, gender, and education. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning and neuropsychological tests. Amplitude of low-frequency fluctuation (ALFF) was calculated to reflect static alterations of regional IBA. Sliding window analysis was conducted in order to explore the dynamic characteristics.

resultsBoth SIVD-CI and SIVD-NCI group showed significantly decreased ALFF in left angular gyrus (ANG), whereas SIVD-CI group showed increased ALFF in right superior frontal gyrus (SFG), compared with HCs. Furthermore, SIVD-CI group showed significantly decreased ALFF dynamics (dALFF) in right precuneus (PreCu) and left dorsal anterior cingulate cortex (dACC), compared with HC and SIVD-NCI groups (Gaussian random field-corrected, voxel-level P < 0.001, cluster-level P < 0.05). No dynamic changes were detected between SIVD-NCI group and HC group. The mean ALFF value in left ANG of SIVD-CI group was correlated with the score of delayed memory scale.

conclusionANG may be a vulnerable brain region in SIVD patients. Temporal dynamic analysis could serve as a sensitive and promising method to investigate IBA alterations in SIVD patients.

Indexed as

Magnetic Resonance ImagingVascular DiseasesBrainBrain MappingGyrus CinguliHumansCognitive impairmentIntrinsic brain activityResting-state functional magnetic resonance imagingSubcortical ischemic vascular diseaseTemporal dynamics analysis

Identifiers

PMID36892613
OpenAlexW4323653523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.