ArticleIntensive care medicine2023
Daily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter study.
Article in Intensive care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence, Factors Associated and Outcomes of Central Venous Catheter-Related Thrombosis in Critically Ill Patients, a Prospective Cohort Study
Comparison of Vascular Catheter-Related Thrombosis and Risk Factors Using Daily Bedside Ultrasonography After Oncologic and Non-Oncologic Major Surgery
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Risk prediction models for central venous catheter-related complications in children: a systematic review.BMC pediatrics · 2026Pooled it
- Efficacy and safety of ultrasound-guided infraclavicular axillary vein cannulation for centrally inserted central catheter placement in critically ill patients: systematic review with meta-analysis and trial sequential analysis.Critical care (London, England) · 2026Pooled it
- Site-specific complications of central venous catheterization under systematic ultrasound guidance: a target trial emulation revisiting the 3SITES study.Critical care (London, England) · 2025Trial
- Article
- Therapeutic Dilemmas in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Diffuse Alveolar Hemorrhage and Venous Thromboembolism.ACR open rheumatology · 2026Article
- Hemostasis disorders: from bleeding to thrombosis.Intensive care medicine · 2025Article
- Risk factor analysis and development of nomogram prediction model for central venous catheter-related thrombosis in burn patients: a retrospective observational study.Thrombosis journal · 2025Article
- Clinical characteristics & outcome of upper body deep vein thrombosis in critically ill patients.The Indian journal of medical research · 2025Observational
- Contact activation of coagulation in newly inserted indwelling catheters.Scientific reports · 2025Observational
- Enhancing prediction and stratifying risk: machine learning and bayesian-learning models for catheter-related thrombosis in chemotherapy patients.BMC cancer · 2025Article
- Venous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort study.Intensive care medicine · 2024Article
- Macro- and microscopic changes in veins with short-term central venous catheters: an observational autopsy study.BMC anesthesiology · 2024Observational
- Establishment and validation of a predictive nomogram for central venous catheter-related thrombosis in cancer patients: a retrospective nested case-control study.Frontiers in oncology · 2024Article
- Advancing the understanding of catheter-related thrombosis in critically ill patients step by step.Intensive care medicine · 2023Article
- Catheter-related thrombosis in critically ill patients: a clinical problem or just a matter of definition?Intensive care medicine · 2023Article
- The cephalic vein access for use in intensive care unit: an alternative approach.Critical care (London, England) · 2023Article
- Catheter-related thromboses in critically ill patients: are they worth looking for?Intensive care medicine · 2023Article
- Outcome of antithrombotic therapy in cancer patients with catheter-related thrombosis: a systematic review.Frontiers in cardiovascular medicine · 2023Review
- Inferior vena cava thrombosis in two adult patients with veno-arterial extracorporeal membrane oxygenation.World journal of emergency medicine · 2023Article
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Authors and funding
24 authors at 17 institutions in 1 country.
Funding
Abstract
purposeCentral venous catheter (CVC)-related thrombosis (CRT) is a known complication in critically ill patients. However, its clinical significance remains unclear. The objective of the study was to evaluate the occurrence and evolution of CRT from CVC insertion to removal.
methodsA prospective multicenter study was conducted in 28 intensive care units (ICUs). Duplex ultrasound was performed daily from CVC insertion until at least 3 days after CVC removal or before patient discharge from the ICU to detect CRT and to follow its progression. CRT diameter and length were measured and diameter > 7 mm was considered extensive.
resultsThe study included 1262 patients. The incidence of CRT was 16.9% (95% confidence interval 14.8-18.9%). CRT was most commonly found in the internal jugular vein. The median time from CVC insertion to CRT onset was 4 (2-7) days, and 12% of CRTs occurred on the first day and 82% within 7 days of CVC insertion. CRT diameters > 5 mm and > 7 mm were found in 48% and 30% of thromboses. Over a 7-day follow-up, CRT diameter remained stable when the CVC was in place, whereas it gradually decreased after CVC removal. The ICU length of stay was longer in patients with CRT than in those without CRT, and the mortality was not different.
conclusionCRT is a frequent complication. It can occur as soon as the CVC is placed and mostly during the first week following catheterization. Half of the thromboses are small but one-third are extensive. They are often non-progressive and may be resolved after CVC removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.