Evidence map›Paper›PMID 36891828›Full record

ReviewThe Plant journal : for cell and molecular biology2023

Plant terpene specialized metabolism: complex networks or simple linear pathways?

Emily R Lanier, Trine Bundgaard Andersen, Björn Hamberger

Abstract readReview
In one paragraph

Review in The Plant journal : for cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  9. Review
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  11. Overexpression of housekeeping geneHorticulture research · 2025
    Article
  12. Article
  13. High-qualityHorticulture research · 2025
    Article
  14. Article
  15. Non-canonical plant metabolism.Nature plants · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emily R Lanier *Department of Biochemistry and Molecular Biology, Michigan State University, Molecular Plant Sciences Building, 1066 Bogue Street, East Lansing, Michigan, 48824, USA.ORCID 0000-0002-1878-4566
Trine Bundgaard Andersen *Department of Biochemistry and Molecular Biology, Michigan State University, Molecular Plant Sciences Building, 1066 Bogue Street, East Lansing, Michigan, 48824, USA.ORCID 0000-0002-5876-1107
Björn HambergerDepartment of Biochemistry and Molecular Biology, Michigan State University, Molecular Plant Sciences Building, 1066 Bogue Street, East Lansing, Michigan, 48824, USA.ORCID 0000-0003-1249-1807

Funding

Plant Biotechnology for Health and SustainabilityT32GM110523 · NIGMS · MICHIGAN STATE UNIVERSITY · PI LAST, ROBERT LOUIS · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM110523
6 · The paper itself

Abstract

From the perspectives of pathway evolution, discovery and engineering of plant specialized metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical models depict biosynthesis typically from an end-point angle and as linear, for example, connecting central and specialized metabolism. As the number of functionally elucidated routes increased, the enzymatic foundation of complex plant chemistries became increasingly well understood. The perception of linear pathway models has been severely challenged. With a focus on plant terpenoid specialized metabolism, we review here illustrative examples supporting that plants have evolved complex networks driving chemical diversification. The completion of several diterpene, sesquiterpene and monoterpene routes shows complex formation of scaffolds and their subsequent functionalization. These networks show that branch points, including multiple sub-routes, mean that metabolic grids are the rule rather than the exception. This concept presents significant implications for biotechnological production.

Indexed as

Alkyl and Aryl TransferasesDiterpenesSesquiterpenesPhylogenyPlant ProteinsPlantsTerpenesAlkyl and Aryl TransferasesDiterpenesPlant ProteinsSesquiterpenesTerpenesbiosynthetic gene clustercytochrome P450enzyme promiscuitymetabolic networkterpene specialized metabolismterpene synthaseUDP-dependent glycosyl-transferases

Identifiers

PMID36891828
PMCPMC11166267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.