Evidence map›Paper›PMID 36891708›Full record

ReviewZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2022

[Research progress on the characteristics of immune tolerant phase and antiviral therapy in children with chronic hepatitis B].

J Li, P Y Fan, W G Hong, M Zhang, F S Wang

Open access · greenAbstract readReviewEnglish Abstract
In one paragraph

Review in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. [Analysis of antiviral efficacy in pediatric patients with HBeAg-negative chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Article
  2. [New progress on the clinical study of antiviral therapy for chronic hepatitis B in children].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J LiDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Peking University 302 Clinical Medical School, Beijing 100191, China.
P Y FanPeking University 302 Clinical Medical School, Beijing 100191, China Department of Liver Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
W G HongDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
M ZhangPeking University 302 Clinical Medical School, Beijing 100191, China Department of Liver Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
F S WangDepartment of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China Peking University 302 Clinical Medical School, Beijing 100191, China.
Chinese PLA General Hospital · CN

Funding

Innovation Groups of the National Natural Science Foundation of China 81721002National Natural Science Foundation 82130019
6 · The paper itself

Abstract

Whether or not children with chronic hepatitis B (CHB) in the immune-tolerant phase need to be treated is one of the hot clinical issues that have not yet been clarified. Thus, in order to make clinical antiviral treatment decisions in children with an immune tolerant phase, a comprehensive understanding of the natural history of HBV infection, as well as its relationship with disease progression and whether prompt treatment can alter the natural history and prognosis, is very important. To that end, this article reviews the research progress of clinical antiviral therapy in the immune-tolerant phase for children with chronic hepatitis B over the last decade, while also discussing the treatment's safety, effectiveness, and related immunological mechanisms, so as to clarify the next key step in research orientation, provide direct evidence-based medical evidence for hepatologists to better diagnose and treat, and ultimately improve the clinical cure rate.

Indexed as

Hepatitis B, ChronicAntiviral AgentsDisease ProgressionHepatitis B e AntigensHepatitis B virusHumansPrognosisAntiviral AgentsHepatitis B e Antigens

Identifiers

PMID36891708
PMCPMC12769811
OpenAlexW4323653336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.