Evidence map›Paper›PMID 36891609›Full record

ArticleThe Journal of physiology2023

Myocardial steatosis impairs left ventricular diastolic-systolic coupling in healthy humans.

Andrew P Oneglia, Lidia S Szczepaniak, Manall F Jaffery, Daisha J Cipher, Jeffrey G McDonald, Mark J Haykowsky, Kerrie L Moreau, Deborah J Clegg, Vlad Zaha, Michael D Nelson

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Observational
  6. Human cardiac metabolism.Cell metabolism · 2024
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Andrew P OnegliaCollege of Nursing and Health Innovation, Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.ORCID 0000-0002-8078-6810
Lidia S SzczepaniakBiomedical Consulting in MRS, Albuquerque, NM, USA.
Manall F JafferyCollege of Nursing and Health Innovation, Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Daisha J CipherCollege of Nursing and Health Innovation, Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Jeffrey G McDonaldCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mark J HaykowskyCollege of Health Sciences, Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.
Kerrie L MoreauDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0001-9298-047X
Deborah J CleggTexas Tech Health Sciences Center, El Paso, TX, USA.
Vlad ZahaAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michael D NelsonCollege of Nursing and Health Innovation, Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.ORCID 0000-0002-3232-8639
The University of Texas at Arlington · USMNM Consulting (France) · FRSouthwestern Medical Center · USThe University of Texas at El Paso · USThe University of Texas Southwestern Medical Center · USUniversity of Alberta · CAUniversity of Colorado Anschutz Medical Campus · US

Funding

TRANSCRIPTIONAL REGULATION OF LDL RECEPTOR PROMOTERP01HL020948 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GOLDSTEIN, JOSEPH L · 1985 to 2021
$103.1M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JAY D. HORTON · 2022 to 2026
$7.4M
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionR01HL136601 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NELSON, MICHAEL DOUGLAS · 2018 to 2022
$3.3M
NHLBI NIH HHS P01 HL020948NHLBI NIH HHS R01 HL136601NIDDK NIH HHS P30 DK127984NIH HHS HL020948
6 · The paper itself

Abstract

Mounting evidence suggests that myocardial steatosis contributes to left ventricular diastolic dysfunction, but definitive evidence in humans is lacking due to confounding comorbidities. As such, we utilized a 48-h food restriction model to acutely increase myocardial triglyceride (mTG) content - measured by

Indexed as

CardiomyopathiesVentricular Dysfunction, LeftAdultDiastoleFemaleHumansMaleMyocardiumTriglyceridesVentricular Function, LeftTriglyceridescouplingdiastolelipotoxicityrelaxationsteatosis

Identifiers

PMID36891609
PMCPMC10318480
OpenAlexW4323653094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.