Evidence map›Paper›PMID 36891530›Full record

ReviewAIMS microbiology2023

Bioactive compounds by microalgae and potentials for the management of some human disease conditions.

Chijioke Nwoye Eze, Chukwu Kenechi Onyejiaka, Stella Amarachi Ihim, Thecla Okeahunwa Ayoka, Chiugo Claret Aduba, Johnson K Ndukwe, Ogueri Nwaiwu, Helen Onyeaka

Abstract readReview
In one paragraph

Review in AIMS microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Photochemical synergy in hybrid sunscreen gels: enhanced UV protection and photostability with algal antioxidants, quercetin, azobenzene, and chitosan-coated TiO₂ nanoparticles.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Current issues in molecular biology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chijioke Nwoye EzeDepartment of Science Laboratory Technology, University of Nigeria Nsukka.
Chukwu Kenechi OnyejiakaDepartment of Microbiology, University of Nigeria Nsukka.
Stella Amarachi IhimDepartment of Pharmacology and Toxicology, Faculty of Pharmaceutical, University of Nigeria Nsukka.
Thecla Okeahunwa AyokaDepartment of Biochemistry, University of Nigeria Nsukka.
Chiugo Claret AdubaDepartment of Science Laboratory Technology, University of Nigeria Nsukka.
Johnson K NdukweDepartment of Microbiology, University of Nigeria Nsukka.
Ogueri NwaiwuSchool of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
Helen OnyeakaSchool of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microalgae biomasses are excellent sources of diverse bioactive compounds such as lipids, polysaccharides, carotenoids, vitamins, phenolics and phycobiliproteins. Large-scale production of these bioactive substances would require microalgae cultivation either in open-culture systems or closed-culture systems. Some of these bioactive compounds (such as polysaccharides, phycobiliproteins and lipids) are produced during their active growth phase. They appear to have antibacterial, antifungal, antiviral, antioxidative, anticancer, neuroprotective and chemo-preventive activities. These properties confer on microalgae the potential for use in the treatment and/or management of several neurologic and cell dysfunction-related disease conditions, including Alzheimer's disease (AD), AIDS and COVID-19, as shown in this review. Although several health benefits have been highlighted, there appears to be a consensus in the literature that the field of microalgae is still fledgling, and more research needs to be carried out to ascertain the mechanisms of action that underpin the effectiveness of microalgal compounds. In this review, two biosynthetic pathways were modeled to help elucidate the mode of action of the bioactive compounds from microalgae and their products. These are carotenoid and phycobilin proteins biosynthetic pathways. The education of the public on the importance of microalgae backed with empirical scientific evidence will go a long way to ensure that the benefits from research investigations are quickly rolled out. The potential application of these microalgae to some human disease conditions was highlighted.

Indexed as

active compoundsAlzheimer's diseasecarotenoidsoxidative stress

Identifiers

PMID36891530
PMCPMC9988413

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.