Evidence map›Paper›PMID 36891528›Full record

ReviewNeurobiology of stress2023

Katherine Bassil, Anthi C Krontira, Thomas Leroy, Alana I H Escoto, Clara Snijders, Cameron D Pernia, R Jeroen Pasterkamp, Laurence de Nijs, Daniel van den Hove, Gunter Kenis and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Neurobiology of stress, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Establishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Katherine BassilDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Anthi C KrontiraDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Thomas LeroyInstitute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Alana I H EscotoDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Clara SnijdersDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Cameron D PerniaDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
R Jeroen PasterkampDepartment of Translational Neuroscience, University Medical Center (UMC) Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
Laurence de NijsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Daniel van den HoveDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Gunter KenisDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Marco P BoksPsychiatry, UMC Utrecht Brain Center, Utrecht, the Netherlands.
Krishna VadodariaSalk Institute for Biological Studies, La Jolla, San Diego, United States.
Nikolaos P DaskalakisDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Bart P F RuttenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
Maastricht University · NLHarvard University · USMax Planck Institute of Psychiatry · DESalk Institute for Biological Studies · USUCLouvain · BEUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamic-pituitary adrenal (HPA)axis dysregulation has long been implicated in stress-related disorders such as major depression and post-traumatic stress disorder. Glucocorticoids (GCs) are released from the adrenal glands as a result of HPA-axis activation. The release of GCs is implicated with several neurobiological changes that are associated with negative consequences of chronic stress and the onset and course of psychiatric disorders. Investigating the underlying neurobiological effects of GCs may help to better understand the pathophysiology of stress-related psychiatric disorders. GCs impact a plethora of neuronal processes at the genetic, epigenetic, cellular, and molecular levels. Given the scarcity and difficulty in accessing human brain samples, 2D and 3D

Indexed as

GlucocorticoidsIn vitro modelsNeurobiologyPsychiatryStressStress disorders

Identifiers

PMID36891528
PMCPMC9986648
OpenAlexW4321602057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.