Evidence map›Paper›PMID 36891526›Full record

ArticleResearch and practice in thrombosis and haemostasis2023

Atrial fibrillation and cancer: prevalence and relative risk from a nationwide study.

Cihan Ay, Ella Grilz, Stephan Nopp, Florian Moik, Oliver Königsbrügge, Peter Klimek, Stefan Thurner, Florian Posch, Ingrid Pabinger

Abstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Impact of CaInternational journal of molecular sciences · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Myeloproliferative Neoplasms and Cardiovascular Disease: A Review.Current treatment options in oncology · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Atrial fibrillation and cancer: Two peas in a pod.Research and practice in thrombosis and haemostasis · 2023
    Article
  16. Breast Cancer and Atrial Fibrillation.Journal of clinical medicine · 2022
    Review
  17. Cancer, Inflammation, and Thrombosis: Drivers of Atrial Fibrillation in Oncology Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cihan AyDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Ella GrilzDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Stephan NoppDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Florian MoikDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Oliver KönigsbrüggeDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Peter KlimekSection for Science of Complex Systems, CEMSIIS, Medical University of Vienna, Vienna, Austria.
Stefan ThurnerSection for Science of Complex Systems, CEMSIIS, Medical University of Vienna, Vienna, Austria.
Florian PoschDepartment of Internal Medicine, Medical University of Graz, Graz, Austria.
Ingrid PabingerDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation (AF) is an increasingly recognized codiagnosis in patients with cancer. Objectives: This study aimed to provide a robust and contemporary estimate on the coprevalence and relative risk of AF in patients with cancer. Methods: We conducted a nationwide analysis, utilizing diagnosis codes from the Austrian Association of Social Security Providers dataset. Estimates of the coprevalence of cancer and AF and the relative risk of AF in patients with cancer compared with individuals without cancer were obtained as point prevalences with binomial exact confidence intervals and summarized across age groups and cancer types with random-effects models. Results: Overall, 8,306,244 persons were included in the present analysis, of whom 158,675 (prevalence estimate, 1.91%; 95% CI, 1.90-1.92) had a cancer diagnosis code and 112,827 (1.36%; 95% CI, 1.35-1.36) an AF diagnosis code, respectively. The prevalence estimate for AF in patients with cancer was 9.77% (95% CI, 9.63-9.92) and 1.19% (95% CI, 1.19-1.20) in the noncancer population. Conversely, 13.74% (95% CI, 13.54-13.94) of patients with AF had a concurrent cancer diagnosis. The corresponding age-stratified random-effects relative risk ratio for AF in patients with cancer compared with no cancer diagnosis was 10.45 (95% CI, 7.47-14.62). The strongest associations between cancer and AF were observed in younger persons and patients with hematologic malignancies. Conclusion: Cancer and AF have a substantial coprevalence in the population. This finding corroborates the concept that cancer and AF have common risk factors and pathophysiology.

Indexed as

atrial fibrillationcancernationwide studyneoplasmsprevalence

Identifiers

PMID36891526
PMCPMC9986100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.