Evidence map›Paper›PMID 36891502›Full record

ArticleFrontiers in oncology2022

Simulation of dosimetric consequences of intrafraction variation of tumor drift in lung cancer stereotactic body radiotherapy.

Bin Han, Bian Wu, Fala Hu, Yangguang Ma, Haiyang Wang, Xinwei Han, Gang Liu, Yuexin Guo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Editorial: Methods in radiation oncology.Frontiers in oncology · 2024
    Article
  6. Review
  7. Mathematical Modeling Support for Lung Cancer Therapy-A Short Review.International journal of molecular sciences · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Bin HanThe First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, China.
Bian WuCancer Center, Union Hospital, Huazhong University of Science and Technology, Tongji Medical College, Wuhan, China.
Fala HuSchool of Mathematics and Statistics, Wuhan University, Hubei, Wuhan, China.
Yangguang MaThe First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, China.
Haiyang WangThe First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, China.
Xinwei HanThe First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, China.
Gang LiuCancer Center, Union Hospital, Huazhong University of Science and Technology, Tongji Medical College, Wuhan, China.
Yuexin GuoThe First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CNHuazhong University of Science and Technology · CNUnion Hospital · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study was to investigate the target dose discrepancy caused by intrafraction variation during stereotactic body radiotherapy (SBRT) for lung cancer. Methods: Intensity-modulated radiation therapy (IMRT) plans were designed based on average computed tomography (AVG CT) utilizing the planning target volume (PTV) surrounding the 65% and 85% prescription isodoses in both phantom and patient cases. Variation was simulated by shifting the nominal plan isocenter along six directions from 0.5 mm to 4.5 mm with a 1-mm step size to produce a series of perturbed plans. The dose discrepancy between the initial plan and the perturbed plans was calculated as the percentage of the initial plan. Dose indices, including Results: We found that motion can lead to serious dose degradation of the target and ITV in lung SBRT, especially during SBRT with PTV surrounding the lower isodose line. Lower isodose line may lead to larger dose discrepancy, while make steeper dose fall-off gradient. This phenomenon was compromised when 3-dimensional space distribution was considered. Discussion: This result may provide a prospective reference for target dose degradation due to motion during lung SBRT treatment.

Indexed as

4D-CTdoseintrafractionSBRTtumor motion

Identifiers

PMID36891502
PMCPMC9987420
OpenAlexW4311870576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.