SynthesisFrontiers in neurology2023
Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis.
Synthesis in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Endovascular thrombectomy plus intravenous thrombolysis versus endovascular thrombectomy alone for large ischemic stroke.Acta neurologica Belgica · 2026Pooled it
- Early versus late anticoagulation treatment after acute ischemic stroke with atrial fibrillation: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Outcomes of mechanical thrombectomy in M1 occlusion patients with or without hyperdense middle cerebral artery sign: A systematic review and meta-analysis.The neuroradiology journal · 2024Pooled it
- Transcranial direct current stimulation is safe and feasible in hyperacute ischemic stroke (DICAST-SF trial).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Risk factors for hemorrhagic transformation after tenecteplase therapy in acute ischemic stroke: A retrospective observational study.Medicine · 2026Observational
- Noncontrast CT-based habitat analysis for differentiating hemorrhagic transformation from contrast extravasation after endovascular therapy of acute ischemic stroke.European radiology experimental · 2026Article
- Clinical Significance of Asymptomatic Intracranial Hemorrhage Following Thrombectomy for Large-Vessel Occlusion: Insight from the ANGEL-ACT Registry.Clinical neuroradiology · 2026Article
- Systemic immune-inflammation index predicts hemorrhagic transformation after endovascular therapy for ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Hemorrhagic transformation following a malignant middle cerebral artery infarction.Journal of cerebrovascular and endovascular neurosurgery · 2026Article
- Brain stroke detection and classification using deep learning-based transCBAMSegNet and hybrid transformer models.Physical and engineering sciences in medicine · 2026Article
- Beyond Recanalization: A Mechanistic and Procedural Framework for Adjunct Pharmacologic Therapy During Mechanical Thrombectomy.Journal of clinical medicine · 2026Review
- Can Dual-Energy CT Be Easily Adopted in Clinical Practice for Predicting Hemorrhagic Complications?Clinical neuroradiology · 2026Article
- Efficacy and safety of adjuvant tirofiban versus intravenous thrombolysis alone in acute ischemic stroke: an updated meta-analysis of randomized controlled trials.Journal of thrombosis and thrombolysis · 2026Review
- Clinical phenotypes of ischaemic stroke patients and early cardiovascular complications: a latent class analysis from the Perugia Stroke Registry.Internal and emergency medicine · 2026Article
- Timosaponin B-II attenuates hemorrhagic transformation-driven acceleration of alzheimer disease-related pathology after ischemic stroke.Biochemistry and biophysics reports · 2026Article
- AI-assisted hemorrhage detection following endovascular stroke treatment: a retrospective diagnostic accuracy study.Neurological research and practice · 2026Article
- Intravenous Thrombolysis for Ischemic Stroke Patients with Pituitary Neoplasms: A Nationwide Study and Scoping Review.NeuroSci · 2026Article
- The Safety and Efficacy of Mechanical Thrombectomy with Acute Carotid Artery Stenting in an Extended Time Window: A Single-Center Study.Medical sciences (Basel, Switzerland) · 2026Article
- Prognostic value of collateral scoring systems for hemorrhagic transformation after endovascular treatment in acute ischemic stroke.Polish journal of radiology · 2026Article
- Risk factors and intervention strategies for lower extremity deep vein thrombosis after intravenous thrombolysis for acute ischemic stroke.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hemorrhagic transformation (HT) following reperfusion therapies for acute ischaemic stroke often predicts a poor prognosis. This systematic review and meta-analysis aims to identify risk factors for HT, and how these vary with hyperacute treatment [intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT)]. Methods: Electronic databases PubMed and EMBASE were used to search relevant studies. Pooled odds ratio (OR) with 95% confidence interval (CI) were estimated. Results: A total of 120 studies were included. Atrial fibrillation and NIHSS score were common predictors for any intracerebral hemorrhage (ICH) after reperfusion therapies (both IVT and EVT), while a hyperdense artery sign (OR = 2.605, 95% CI 1.212-5.599, Conclusion: Several predictors of ICH were identified, which varied by treatment type. Studies based on larger and multi-center data sets should be prioritized to confirm the results. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=268927, identifier: CRD42021268927.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.