Evidence map›Paper›PMID 36891407›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2023

Pembrolizumab-Induced Giant Cell Arteritis in the Setting of Urothelial Carcinoma.

Deanna Ingrassia Miano, Ryan Cosgrove, Joshua Sherman, Savitha Balaraman, Michael Sherman

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Deanna Ingrassia MianoDepartment of Ophthalmology, Ascension Eye Institute - Ascension Macomb-Oakland Hospital, Warren, Michigan, USA.ORCID https://orcid.org/0000-0001-7434-4955
Ryan CosgroveDepartment of Ophthalmology, Ascension Eye Institute - Ascension Macomb-Oakland Hospital, Warren, Michigan, USA.ORCID https://orcid.org/0000-0001-7637-4066
Joshua ShermanLyman Briggs College, Michigan State University, East Lansing, Michigan, USA.
Savitha BalaramanDepartment of Oncology, Beaumont Health, Royal Oak, Michigan, USA.
Michael ShermanDepartment of Ophthalmology, Ascension Eye Institute - Ascension Macomb-Oakland Hospital, Warren, Michigan, USA.
Ascension · USBeaumont Health · USMichigan State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 65-year-old male presented to the Ophthalmology clinic with painless loss of vision in his right eye. Over the previous week the right eye's vision had progressed from being blurry to complete loss. Three weeks prior to presentation he had begun treatment with pembrolizumab for urothelial carcinoma. Ophthalmological assessment and subsequent imaging prompted further investigation, and a temporal artery biopsy confirmed a diagnosis of giant cell arteritis. This case demonstrates a rare, yet serious, condition of biopsy-confirmed giant cell arteritis in the setting of pembrolizumab treatment for urothelial carcinoma. In addition to reporting a vision threatening side effect of pembrolizumab we emphasise the need for vigilant care of patients on this drug as symptomatology and laboratory results may be inconspicuous.

Indexed as

giant cell arteritisoncologyPembrolizumabvision loss

Identifiers

PMID36891407
PMCPMC9988338
OpenAlexW4294912062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.