ReviewNeuro-ophthalmology (Aeolus Press)2023
Different Characteristics of Pre-Pubertal and Post-Pubertal Idiopathic Intracranial Hypertension: A Narrative Review.
Review in Neuro-ophthalmology (Aeolus Press), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Therapeutic role of venous sinus stenting in pediatric IIH: evidence review for clinical practice.Acta neurochirurgica · 2025Pooled it
- Incidence of idiopathic intracranial hypertension (IIH) in adults and children: a 14-year population-based study.Journal of neurology · 2026Article
- Article
- Neuro-interventional Radiology in Paediatric Patients: An Update.Cardiovascular and interventional radiology · 2025Review
- Idiopathic Intracranial Hypertension in Children and Adolescents with Obesity: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Current Understanding of the Pathophysiology of Idiopathic Intracranial Hypertension.Current neurology and neuroscience reports · 2025Review
- Paediatric IIH: Are There Differences in Visual Outcomes and Recurrence Rates?Neuro-ophthalmology (Aeolus Press) · 2025Article
- Cranial vault expansion in treatment of paediatric idiopathic intracranial hypertension.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Vaulting further: cranial vault expansion for craniocerebral disproportion without primary craniosynostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions.The AAPS journal · 2024Article
- Managing idiopathic intracranial hypertension in the eye clinic.Eye (London, England) · 2024Review
- Fulminant Idiopathic Intracranial Hypertension Should Be Redefined Without a Time Limited Definition: In reply to: Characterisation and visual outcomes of fulminant idiopathic intracranial hypertension: a narrative review.Neuro-ophthalmology (Aeolus Press) · 2024Article
- The Pressure of Headache at the United Kingdom CSF Disorders Day 2023.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Asymptomatic idiopathic intracranial hypertension: Prevalence and prognosis.Clinical & experimental ophthalmology · 2023Observational
- A Neuro-Ophthalmologist's Guide to Advances in Intracranial Pressure Measurements.Eye and brain · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic intracranial hypertension (IIH) affects both children and adults. There are currently no clinical trials in IIH for those who are adolescents or children. The aims of this narrative review were to characterise the differences between pre- and post-pubertal IIH and to highlight the need to be more inclusive in clinical trial planning and recruitment. A detailed search of the scientific literature was performed using the PubMed database, from inception until 30 May 2022 using keywords. This included English language papers only. The abstracts and full texts were reviewed by two independent assessors. The literature revealed that the pre-pubertal group had a more variable presentation. The presenting features in the post-pubertal paediatric group were more akin to adults with headache as the dominant feature. They were also more likely to be female and have an increased body mass index. A clear limitation of the literature was that a number of paediatric studies had variable inclusion criteria, including secondary causes of raised intracranial pressure. Pre-pubertal children do not display the same predilection towards the female sex and obesity as post-pubertal children, who have a similar phenotype to the adult cohort. Inclusion of adolescents in clinical trials should be considered given the similar phenotype to adults. There is a lack of consistency in the definition of puberty, making the IIH literature difficult to compare. Inclusion of secondary causes of raised intracranial pressure has the potential to confound the accuracy of analysis and interpretation of the results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.