Evidence map›Paper›PMID 36891378›Full record

ArticleInfection and drug resistance2023

Carbapenem-Resistant and ESBL-Producing Enterobacterales Emerging in Central Texas.

Jennifer K Parker, Richard Gu, Gregory A Estrera, Betsy Kirkpatrick, Dusten T Rose, Despoina A I Mavridou, Kristin E Mondy, Bryan W Davies

Abstract read
In one paragraph

Article in Infection and drug resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer K ParkerDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-4382-0741
Richard GuDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Gregory A EstreraDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Betsy KirkpatrickAustin Public Health, City of Austin, Austin, TX, USA.
Dusten T RoseDepartment of Pharmacy, Ascension Seton, Dell Seton Medical Center at The University of Texas, Austin, TX, USA.ORCID 0000-0002-1710-336X
Despoina A I MavridouDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-7449-1151
Kristin E MondyDepartment of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-5278-6162
Bryan W DaviesDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-2046-0341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Carbapenem-resistant Enterobacterales (CRE) are subject to intense global monitoring in an attempt to maintain awareness of prevalent and emerging resistance mechanisms and to inform treatment and infection prevention strategies. CRE and extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are not usually examined collectively in regards to their shared pool of resistance determinants. Here, we genetically and phenotypically assess clinical isolates of CRE and extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales in the growing region of Central Texas, where CRE are emergent and occurrence of non-carbapenemase-producing-CRE (non-CP-CRE) infections is increasing. Methods: CRE (n=16) and ESBL-producing Enterobacterales (n=116) isolates were acquired from a regional hospital in Central Texas between December 2018 and January 2020. Isolates were assessed genetically and phenotypically using antibiotic susceptibility testing, targeted PCR, and whole genome sequencing. Results: CRE infections are increasing in incidence in Central Texas, and Conclusion:

Indexed as

beta-lactamcarbapenemasecolicingeneticsKlebsiella

Identifiers

PMID36891378
PMCPMC9987243

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.