SynthesisThe Journal of clinical pediatric dentistry2023
Effects of probiotics on preventing caries in preschool children: a systematic review and meta-analysis.
Synthesis in The Journal of clinical pediatric dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06063239 (Probiotics in Special Needs Patients at High Risk for Tooth Decay), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of probiotic interventions on oral health in children: a systematic review.Frontiers in dental medicine · 2026Pooled it
- Unlocking the potential of probiotic administration in caries management: a systematic review.BMC oral health · 2024Pooled it
- A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality.Nature human behaviour · 2023Pooled it
- Probiotics Partly Suppress the Impact of Sugar Stress on the Oral Microbiota-A Randomized, Double-Blinded, Placebo-Controlled Trial.Nutrients · 2023Trial
- Probiotic Bifidobacterium animalis subsp. lactis BL-11 attenuates dental caries development in a Streptococcus mutans-induced rat model.Odontology · 2026Article
- State-of-the-Art Review on Probiotics, Synbiotics, and Microbial Metabolites: Molecular Mechanisms Shaping Host Immunity, Metabolic Health, and Chronic Disease Prevention.Molecular nutrition & food research · 2026Review
- Effects of Oral Probiotics onDentistry journal · 2026Review
- The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses.Frontiers in oral health · 2026Review
- Oral Lichenoid Reactions Caused by Mesalazine for Treatment of Ulcerative Colitis: A Case Report and Review of the Literature.Case reports in dentistry · 2026Article
- Streptococcus mutans Growth Inhibition by the Probiotic Lacticaseibacillus rhamnosus GG as an Additive to Infant Formula.International journal of paediatric dentistry · 2026Article
- Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.Dentistry journal · 2025Review
- Article
- Gut Microbiome Interventions: From Dysbiosis to Next-Generation Probiotics (NGPs) for Disease Management.Probiotics and antimicrobial proteins · 2025Review
- Lactoferrin Solution as a New Natural Photosensitizer in Photodynamic Therapy Against OralMicroorganisms · 2025Article
- Editorial for Oral Microbes and Human Health.Microorganisms · 2025Article
- Article
- Clinical and Technological Evaluation of the Remineralising Effect of Biomimetic Hydroxyapatite in a Population Aged 6 to 18 Years: A Randomized Clinical Trial.Bioengineering (Basel, Switzerland) · 2025Article
- Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges.World journal of stem cells · 2025Article
- The Home Use of Probiotics and Paraprobiotics for the Maintenance of Tongue Eubiosis: A Case Report.Case reports in dentistry · 2025Article
- Streptococcus cristatus reduces cariogenicity of saliva-derived microcosms under pH-dependent conditions.Journal of oral microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This paper systematically evaluate the effects of probiotics on preventing caries in preschool children. The present systematic review was conducted following the Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines and recorded in the International prospective register of systematic reviews (PROSPERO) database (registration no: CRD42022325286). Literature were screened from PubMed, Embase, Web of Sciences, China National Knowledge Infrastructure (CNKI), Wanfang and other databases from inception to April 2022 to identify randomized controlled trials on the clinical efficacies of probiotics in preventing dental caries in preschool children and extract relevant data. The meta-analysis was performed using the RevMan5.4 software and the Stata16. Cochrane handbook was used to assess the risk of bias. The Grading of Recommendations Assessment, Development and Evaluation (GRADEprofiler 3.6) was used to determine the evidence quality. A total of 17 randomized controlled trials were eligible, of which two trials had certain levels of bias and 15 had a low risk of bias. Evidence quality assessment showed that the included trials were of medium quality. The meta-analysis results showed that
Indexed as
Identifiers
36890746What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.