ArticleThe Plant cell2023
Functional interdependence of N6-methyladenosine methyltransferase complex subunits in Arabidopsis.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
- RNA m6A methylation fine-tunes the jasmonic acid biosynthesis pathway to modulate plant aging.The Plant cell · 2026Article
- Phytochrome B and the methyltransferase complex coordinately regulate NPlant communications · 2026Article
- Mapping the dynamic plant interactome: from in vitro assays to in vivo quantitative approaches.Plant methods · 2026Review
- Genome-Wide Characterization of theGenes · 2026Article
- Genome-wide identification and expression analysis of YTH gene family in barley reveals their potential role under abiotic stresses.Genetica · 2026Article
- The mFrontiers in plant science · 2026Review
- Identification of writers and erasers in tomato and their response to drought stress and hormones.Plant cell reports · 2025Article
- Functional and clinical significance of the RNA mNPJ breast cancer · 2025Article
- A mutually antagonistic mechanism mediated by RNA mNature communications · 2025Article
- RNA mNature plants · 2025Article
- Epitranscriptomic reprogramming in response to low COThe Plant journal : for cell and molecular biology · 2025Article
- Molecular mechanisms and crop improvement potential of RNA NaBIOTECH · 2025Review
- SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice.Nature communications · 2025Article
- Comprehensive genomic characterization and differential expression analysis of mBMC plant biology · 2025Article
- MdDSK2a-Like-MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Genome-Wide Identification and Expression Analysis of the YTH Domain-Containing Protein Gene Family inInternational journal of molecular sciences · 2025Article
- NNature communications · 2025Article
- RNA mNature plants · 2025Review
- Characterization of the mInternational journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Addition of N6-methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is catalyzed by an evolutionarily conserved m6A methyltransferase complex. In the model plant Arabidopsis thaliana, the m6A methyltransferase complex is composed of 2 core methyltransferases, mRNA adenosine methylase (MTA) and MTB, and several accessory subunits such as FK506-BINDING PROTEIN 12 KD INTERACTING PROTEIN 37KD (FIP37), VIRILIZER (VIR), and HAKAI. It is yet largely unknown whether these accessory subunits influence the functions of MTA and MTB. Herein, I reveal that FIP37 and VIR are indispensable for stabilizing the methyltransferases MTA and MTB, thus functioning as key subunits to maintain the functionality of the m6A methyltransferase complex. Furthermore, VIR affects FIP37 and HAKAI protein accumulation, while MTA and MTB mutually influence each other. In contrast, HAKAI has little effect on protein abundance or localization of MTA, MTB, and FIP37. These findings uncover unique functional interdependence at the post-translational level among individual components in the Arabidopsis m6A methyltransferase complex, suggesting that maintenance of protein homeostasis among various subunits of the m6A methyltransferase complex is essential for maintaining the protein stoichiometry required for the proper function of the m6A methyltransferase complex in m6A deposition in plants.
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