Evidence map›Paper›PMID 36890702›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Retrospective Analysis of Direct-Acting Oral Anticoagulants (DOACs) Initiation Timing and Outcomes After Thrombolysis in High- and Intermediate-Risk Pulmonary Embolism.

Adam Wolfe, Angela Phillips, David M Tierney, Roman Melamed, Ghazi Qadri, Matthew Lillyblad, Claire Smith, Catherine St Hill, Ashley E Stenzel, David Beddow and 3 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Specific Reversal Agents for Direct Oral Anticoagulants in Acute Stroke.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Adam WolfeDepartment of Graduate Medical Education, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Angela PhillipsDepartment of Graduate Medical Education, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
David M TierneyDepartment of Graduate Medical Education, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.ORCID 0000-0003-4202-1101
Roman MelamedDepartment of Critical Care, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.ORCID 0000-0001-6187-1414
Ghazi QadriDepartment of Internal Medicine, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Matthew LillybladDepartment of Pharmacy, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Claire SmithCare Delivery Research, 5531Allina Health, Minneapolis, MN, USA.ORCID 0000-0002-4979-2104
Catherine St HillCare Delivery Research, 5531Allina Health, Minneapolis, MN, USA.
Ashley E StenzelCare Delivery Research, 5531Allina Health, Minneapolis, MN, USA.
David BeddowDepartment of Internal Medicine, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Justin KirvenDepartment of Internal Medicine, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Rajesh KethireddyDepartment of Internal Medicine, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.
Love PatelDepartment of Internal Medicine, 21878Abbott Northwestern Hospital, 5531Allina Health, Minneapolis, MN, USA.ORCID 0000-0002-6271-6376
Abbott Northwestern Hospital · USAllina Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct-acting oral anticoagulants (DOACs) are prescribed in the treatment of venous thromboembolism, including pulmonary embolism (PE). Evidence is limited regarding the outcomes and optimal timing of DOACs in patients with intermediate- or high-risk PE treated with thrombolysis. We conducted a retrospective analysis of outcomes among patients with intermediate- and high-risk PE who received thrombolysis, by choice of long-term anticoagulant agent. Outcomes of interest included hospital length of stay (LOS), intensive care unit LOS, bleeding, stroke, readmission, and mortality. Descriptive statistics were used to examine characteristics and outcomes among patients, by anticoagulation group. Patients receiving a DOAC (n = 53) had shorter hospital LOS compared to those in warfarin (n = 39) and enoxaparin (n = 10) groups (mean LOS 3.6, 6.3 and 4.5 days, respectively;

Indexed as

Factor Xa InhibitorsPulmonary EmbolismAdministration, OralAnticoagulantsHumansRetrospective StudiesRivaroxabanThrombolytic TherapyAnticoagulantsFactor Xa InhibitorsRivaroxabananticoagulation, DOACpulmonary embolismthrombolytic

Identifiers

PMID36890702
PMCPMC9998410
OpenAlexW4323652691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.