ArticleBMC neurology2023
Epidemiological and clinical characteristics predictive of ICU mortality of patients with traumatic brain injury treated at a trauma referral hospital - a cohort study.
Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Survival status, mortality predictors, and scores in patients with severe traumatic brain injury in the intensive care unit.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Glasgow coma scale-pupils at 24-hours as a reliable marker for extremely poor prognosis in traumatic brain injury - A prospective cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- Impact of Invasive Intracranial Pressure Monitoring on Outcomes in Older Adults with Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Article
- Pathway-level proteomics identifies subcellular trafficking dysregulation as a molecular signature in severe traumatic brain injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Potential Protective Effects of Naloxone in Traumatic Brain Injury Through JAK2/STAT3 Signaling Modulation.Life (Basel, Switzerland) · 2026Article
- Extradural hematoma management: A case-control study with historical controls reassessing the 'zero mortality' goal.Brain & spine · 2026Article
- Functional recovery of patients with moderate and severe traumatic brain injury after extended and standard early rehabilitation.Frontiers in human neuroscience · 2026Article
- Assessment of optic nerve sheath diameter using ultrasonography in patients with clinical and radiological suspicion of elevated ıntracranial pressure in the ıntensive care unit.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Article
- Predictors of Morbidity and Mortality After Fall-related Traumatic Brain Injury.Orthopedic reviews · 2025Article
- The effect of extended early rehabilitation on the treatment outcome of patients with moderate and severe traumatic brain injury.Frontiers in human neuroscience · 2025Article
- Sex differences and gender-oriented characteristics in intensive care unit admissions for patients with traumatic brain injury in Spain.Frontiers in medicine · 2025Article
- Article
- Letter to the editor: Early hypocoagulable state in traumatic brain injury patients: incidence, predisposing factors, and outcomes in a retrospective cohort study.Neurosurgical review · 2024Article
- Investigating Factors Affecting Mortality Due to Spinal Cord Trauma in Patients Admitted to the Intensive Care Unit.Bulletin of emergency and trauma · 2024Article
- Identifying predictive factors for mortality in patients with TBI at a neurosurgery department.Journal of medicine and life · 2023Observational
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11 authors.
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Abstract
backgroundTraumatic brain injury (TBI) has substantial physical, psychological, social and economic impacts, with high rates of morbidity and mortality. Considering its high incidence, the aim of this study was to identify epidemiological and clinical characteristics that predict mortality in patients hospitalized for TBI in intensive care units (ICUs).
methodsA retrospective cohort study was carried out with patients over 18 years old with TBI admitted to an ICU of a Brazilian trauma referral hospital between January 2012 and August 2019. TBI was compared with other traumas in terms of clinical characteristics of ICU admission and outcome. Univariate and multivariate analyses were used to estimate the odds ratio for mortality.
resultsOf the 4816 patients included, 1114 had TBI, with a predominance of males (85.1%). Compared with patients with other traumas, patients with TBI had a lower mean age (45.3 ± 19.1 versus 57.1 ± 24.1 years, p < 0.001), higher median APACHE II (19 versus 15, p < 0.001) and SOFA (6 versus 3, p < 0.001) scores, lower median Glasgow Coma Scale (GCS) score (10 versus 15, p < 0.001), higher median length of stay (7 days versus 4 days, p < 0.001) and higher mortality (27.6% versus 13.3%, p < 0.001). In the multivariate analysis, the predictors of mortality were older age (OR: 1.008 [1.002-1.015], p = 0.016), higher APACHE II score (OR: 1.180 [1.155-1.204], p < 0.001), lower GCS score for the first 24 h (OR: 0.730 [0.700-0.760], p < 0.001), greater number of brain injuries and presence of associated chest trauma (OR: 1.727 [1.192-2.501], p < 0.001).
conclusionPatients admitted to the ICU for TBI were younger and had worse prognostic scores, longer hospital stays and higher mortality than those admitted to the ICU for other traumas. The independent predictors of mortality were older age, high APACHE II score, low GCS score, number of brain injuries and association with chest trauma.
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