Trial reportBMC geriatrics2023
Association of depressive disorders and dementia with mortality among older people with hip fracture.
Trial report in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of adjunctive esketamine on depression in elderly patients undergoing hip fracture surgery: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Association between preoperative fear of falling and mortality after hip fracture surgery in older adults: a post-hoc analysis of a prospective cohort.European geriatric medicine · 2026Article
- Factors associated with one-year mortality after hip fracture in people older than 85 years in Northern Sweden.European geriatric medicine · 2026Article
- Risk of depression after new-onset dementia or cognitive impairment: the Health and Retirement Study.Innovation in aging · 2026Article
- General Anesthesia in Psychiatric Patients Undergoing Orthopedic Surgery: A Mechanistic Narrative Review-Reports (MDPI) · 2025Review
- Depressive symptoms are associated with mortality among patients with hip fractures in Japan: a prospective cohort study.BMC musculoskeletal disorders · 2025Article
- Association of the overlap of cognitive impairment and depression with 6-month mortality in hospitalized older adults: results from the Re.Po.SI register.BMC geriatrics · 2025Article
- The vulnerability of hip fracture patients with cognitive impairment: an analysis of health conditions, hospital care, and outcomes.BMC geriatrics · 2025Article
- Late-onset major depressive disorder: exploring the therapeutic potential of enhancing cerebral brain-derived neurotrophic factor expression through targeted microRNA delivery.Translational psychiatry · 2024Review
- Cognitive assessment to optimize prediction of functional outcome in subacute hip fracture: a short-term prospective study.European journal of physical and rehabilitation medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHip fracture (HF) is a significant cause of mortality among older people. Almost half of the patients with HF have dementia, which increases the mortality risk further. Cognitive impairment is associated with depressive disorders (DDs) and both dementia and DDs are independent risk factors for poor outcome after HF. However, most studies that evaluate mortality risk after HF separate these conditions.
aimsTo investigate whether dementia with depressive disorders (DDwD) affects the mortality risk at 12, 24, and 36 months after HF among older people.
methodsPatients with acute HF (n = 404) were included in this retrospective analysis of two randomized controlled trials performed in orthopedic and geriatric departments. Depressive symptoms were assessed using the Geriatric Depression Scale and cognitive function was assessed using the Mini-Mental State Examination. A consultant geriatrician made final depressive disorder and dementia diagnoses using the Diagnostic and Statistical Manual of Mental Disorders criteria, with support from assessments and medical records. The 12-, 24- and 36-month mortality after HF was analyzed using logistic regression models adjusted for covariates.
resultsIn analyses adjusted for age, sex, comorbidity, pre-fracture walking ability, and fracture type, patients with DDwD had increased mortality risks at 12 [odds ratio (OR) 4.67, 95% confidence interval (CI) 1.75-12.51], 24 (OR 3.61, 95% CI 1.71-7.60), and 36 (OR 4.53, 95% CI 2.24-9.14) months. Similar results were obtained for patients with dementia, but not depressive disorders, alone.
conclusionDDwD is an important risk factor for increased mortality at 12, 24, and 36 months after HF among older people. Routinely assessments after HF for cognitive- and depressive disorders could identify patients at risk for increased mortality, and enable early interventions.
trial registrationRCT2: International Standard Randomized Controlled Trial Number Register, trial registration number: ISRCTN15738119.
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