SynthesisEvidence-based dentistry2023
The effect of periapical lesion size on the success rate of different endodontic treatments: a systematic review and meta-analysis.
Synthesis in Evidence-based dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- The outcome of combined use of iRoot BP Plus and iRoot SP for root-end filling in endodontic microsurgery: a randomized controlled trial.Clinical oral investigations · 2024Trial
- Cross-Sectional Study on the Relationship of Some Prognostic Factors of Endodontic Treatment With the Presence and Size of Periapical Lesions in Endodontically Treated Mandibular Anterior and Premolar Teeth Using Cone-Beam Computed Tomography.International journal of dentistry · 2026Article
- The effect of periodontal status and coronal restoration quality on early and late term failures in root canal-treated teeth.BMC oral health · 2025Observational
- Determination of a safe protocol for using laser ablation with indocyanine green dye in endodontic treatment. In vitro, in vivo and human study.Lasers in medical science · 2025Article
- Radiographic signature in apical periodontitis improves prediction of apical lesion healing through survival prediction model.PloS one · 2025Article
- Comparison of the Effectiveness of Single-Visit and Multi-Visit Root Canal Treatment on Healing Intraoral Sinus Tract.International journal of dentistry · 2025Article
- Conservative Management of a Large Periapical Lesion Using Decompression Technique: A Case Report.Iranian endodontic journal · 2025Article
- Assessment of Periodontitis Risk Factors in Endodontically Treated Teeth: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
- Outcomes of nonsurgical endodontic treatment under general anesthesia in special health care needs: An observational study.BDJ open · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis systematic review evaluated the effect of periapical lesion (PL) size on the success rate of different endodontic treatments, including root canal treatment (RCT), non-surgical retreatment (NSR), and apical surgery (AS).
methodsCohorts and randomized controlled trials investigating the outcomes of endodontic treatment of permanent teeth with PL and its size were identified electronically through Web of Science, MEDLINE, Scopus, and Embase databases. Two reviewers independently conducted the study selection, data extraction, and critical appraisal process. The quality of the included studies was evaluated using the Newcastle-Ottawa Scale and the 11-item Critical Appraisal Skills Program checklist for randomized controlled trials. The success rates of the endodontic treatments (small lesions and large lesions) were estimated using the rate ratios (RRs) with an associated 95% confidence interval (CI).
resultsOut of 44 included studies, 42 were cohort, and 2 were randomized controlled trials. Thirty-two studies had poor quality. For the meta-analysis, five studies in RCT, 4 in NSR, and 3 in AS were considered. The RR of the endodontic treatment success in PLs was 1.04 in RCT (95% CI, 0.99-1.07), 1.11 in NSR (95% CI, 0.99-1.24), and 1.06 in AS (95% CI, 0.97-1.16). Only sub-group analysis of long-term follow-up of RCT showed a significantly higher success rate in small lesions than in large lesions.
conclusionsConsidering the quality of studies and variation in outcomes and size classification, our meta-analysis demonstrated that the PL size had no significant effect on the success rate of different endodontic treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.