Evidence map›Paper›PMID 36890237›Full record

ArticleNature2023

An airway-to-brain sensory pathway mediates influenza-induced sickness.

Na-Ryum Bin, Sara L Prescott, Nao Horio, Yandan Wang, Isaac M Chiu, Stephen D Liberles

Open access · hybridFull text read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
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  9. Article
  10. Article
  11. Article
  12. Nociceptor neurons shape antiviral immunity.Journal of neuroinflammation · 2026
    Review
  13. Review
  14. Inflammatory mediators of mRNA vaccine-induced adverse reactions in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  15. Article
  16. Review
  17. A non-canonical role ofbioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Na-Ryum BinHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Sara L PrescottHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Nao HorioHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Yandan WangHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1528-351X
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0723-4841
Stephen D LiberlesHoward Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Stephen_Liberles@hms.harvard.edu.ORCID http://orcid.org/0000-0002-2177-9741
Howard Hughes Medical Institute · USHarvard University · US

Funding

Sensory receptors of the vagus nerveDP1AT009497 · NCCIH · HARVARD MEDICAL SCHOOL · PI LIBERLES, STEPHEN DANIEL · 2016 to 2020
$5.9M
Sensory biology of respiratory control neurons in the vagus nerveR01HL132255 · NHLBI · HARVARD MEDICAL SCHOOL · PI LIBERLES, STEPHEN DANIEL · 2016 to 2019
$1.7M
NCCIH NIH HHS DP1 AT009497NHLBI NIH HHS R01 HL132255
6 · The paper itself

Abstract

Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes

Indexed as

Blood-Brain BarrierBrainDinoprostoneNasopharynxOrthomyxoviridae InfectionsSensory Receptor CellsAnimalsBehavior, AnimalBrain StemCyclooxygenase 2DrinkingEatingHumansInfluenza, HumanMiceMovementCyclooxygenase 2DinoprostoneGabra1 protein, mousePtger3 protein, mousePtgs2 protein, mouseReceptors, GABA-AReceptors, Prostaglandin E, EP3 Subtype

Identifiers

PMID36890237
PMCPMC10033449
OpenAlexW4323546561

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read102
reference markers read4
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.