ArticleNature2023
Fumarate induces vesicular release of mtDNA to drive innate immunity.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers.
0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed
46.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
197 citing papers in PubMed, 283 citations in OpenAlex.
- Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease.Haematologica · 2024Trial
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Itaconation and Succination as Metabolite-Derived Cysteine Modifications in Inflammatory Signalling: Biochemical Mechanisms, Chemoproteomic Mapping, and Therapeutic Opportunities.Cell biochemistry and biophysics · 2026Review
- Metabolic reprogramming-mediated therapeutic resistance in renal cell carcinoma: Mechanisms and targeted intervention strategies.iScience · 2026Review
- Nucleic acid sensing pathways in kidney disease development.Nature reviews. Nephrology · 2026Review
- cGAS-STING pathway modulation: A new hope for neural regeneration.Neural regeneration research · 2026Article
- The cGAS-STING pathway in inflammaging and neuroinflammation.Science China. Life sciences · 2026Review
- Fumarate hydratase downregulation in myocardial tissue: a potential biomarker for death from mechanical asphyxia.Forensic science, medicine, and pathology · 2026Article
- Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review).International journal of molecular medicine · 2026Review
- Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.PLoS biology · 2026Article
- Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma.Life science alliance · 2026Article
- PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming.Cell death and differentiation · 2026Article
- Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis.The Journal of clinical investigation · 2026Article
- The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial Gate.bioRxiv : the preprint server for biology · 2026Article
- Aberrant mitochondria in endometriosis: From pathogenic mechanisms to therapeutic opportunities.iScience · 2026Review
- Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets.Journal of the American Heart Association · 2026Review
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- ZG16 represses tumor progression and M2 polarization of tumor-associated macrophages in hepatocellular carcinoma by promoting ubiquitination and degradation of SNX9 via binding to ITCH.Hepatology international · 2026Article
- Amino Acids as Targets for Immunotherapy against Solid Tumors.Cell biochemistry and biophysics · 2026Review
137 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 8 countries.
Vincent Zecchini *Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1686-6602
Vincent Paupe *Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Irene Herranz-MontoyaMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9644-0585
Joëlle JanssenMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Inge M N WortelMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Jordan L MorrisMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Ashley FergusonMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Suvagata Roy ChowduryMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Marc Segarra-MondejarMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Ana S H CostaMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8932-6370
Gonçalo C PereiraMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9638-0615
Laura TronciMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1217-4046
Timothy YoungMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Efterpi NikitopoulouMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Ming YangMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Dóra BiharyMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Federico CaicciDepartment of Biology, University of Padova, Padova, Italy.
Shun NagashimaMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Alyson SpeedMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
Kalliopi BokeaDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, UCL, London, UK.
Zara BaigDivision of Infection and Immunity, Institute of Immunity and Transplantation, UCL, London, UK.
Shamith SamarajiwaMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1046-0601
Maxine TranDepartment of Surgical Biotechnology, Division of Surgery and Interventional Science, UCL, London, UK.
Thomas MitchellWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0003-0761-9503
Mark JohnsonMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Julien PrudentMedical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. julien.prudent@mrc-mbu.cam.ac.uk.ORCID 0000-0003-3821-6088
Christian FrezzaMedical Research Council Cancer Unit, University of Cambridge, Cambridge, UK. christian.frezza@uni-koeln.de.ORCID 0000-0002-3293-7397
University of Cambridge · GBUniversity College London · GBUniversity of Cologne · DECentre for Immunity, Infection and Evolution · GBRadboud University Nijmegen · NLTH Köln - University of Applied Sciences · DETokyo University of Pharmacy and Life Sciences · JPUniversity of Padua · IT
Funding
Cancer Research UK 27176Medical Research Council MC_UU_12022/6
Abstract
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma
Indexed as
DNA, MitochondrialFumaratesImmunity, InnateMitochondriaAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytosolDNA-Binding ProteinsFumarate HydrataseKidneyMiceProtein Serine-Threonine KinasesSorting NexinsSTING ProteinTrans-ActivatorsBRINP3 protein, humancGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA-Binding ProteinsDNA, MitochondrialFumarate HydrataseFumaratesProtein Serine-Threonine KinasesRai1 protein, mouseSNX9 protein, mouseSorting NexinsSting1 protein, mouseSTING ProteinTbk1 protein, mouseTrans-Activators
Identifiers
What OpenQuestion holds
Textfull text, public
LicenceCC BY
reference markers read1
measurements read167
identifiers read1
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.