ArticleNature2023
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
33.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
155 citing papers in PubMed, 207 citations in OpenAlex.
- Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.Nature medicine · 2026Trial
- Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Itaconation and Succination as Metabolite-Derived Cysteine Modifications in Inflammatory Signalling: Biochemical Mechanisms, Chemoproteomic Mapping, and Therapeutic Opportunities.Cell biochemistry and biophysics · 2026Review
- Chronic type II interferon promotes tumor growth through mitochondrial RNA-induced type I interferon and prostaglandin synthesis.Science (New York, N.Y.) · 2026Article
- ASS1-derived argininosuccinate promotes purine nucleoside synthesis in B cell acute lymphoblastic leukaemia.Nature metabolism · 2026Article
- Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.Science advances · 2026Article
- Mitochondrial RNA-Type I Interferon Axis in Sjögren's Disease: Molecular Mechanisms and Translational Implications.International journal of molecular sciences · 2026Review
- Metformin Attenuates Sepsis-Induced Cardiomyopathy via Inhibition of Reverse Electron Transfer at Mitochondrial Complex I.Biology · 2026Article
- Transcriptomics of type 1 diabetes progression: a validation study in newly diagnosed patients.EBioMedicine · 2026Article
- Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis.The Journal of clinical investigation · 2026Article
- Transcriptomic Evidence of Mitochondrial Double-Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease.Aging cell · 2026Article
- Energetic metabolism-regulatory glycopeptide hydrogel accelerates pressure ulcer wound repair.Bioactive materials · 2026Article
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
- Metabolic Perspective on Atherosclerosis: Macrophage Reprogramming and Novel Therapeutic Targets.Journal of the American Heart Association · 2026Review
- Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints.Journal of advanced research · 2026Review
- Stimulator of interferon genes (STING) in renal tumors: Biological bases, diagnostic relevance, and predictive potential.Histology and histopathology · 2026Review
- Macrophage MERTK restrains GRAMD1A-driven mitochondrial oxysterol trafficking to limit colitis.Redox biology · 2026Article
- Argonaute 2 drives resistance to immune checkpoint inhibitors in immunorefractory non-small cell lung cancer.PLoS biology · 2026Article
- Metabolites as signalling molecules in the tumour immune microenvironment.Nature reviews. Immunology · 2026Review
- Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation.Nature communications · 2026Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 6 countries.
Alexander Hooftman *School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. ahooftma@tcd.ie.ORCID 0000-0002-5412-4012
Christian G Peace *School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0002-5390-6530
Dylan G Ryan *School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. dr523@cam.ac.uk.ORCID 0000-0003-4553-9192
Emily A DaySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-3245-5715
Ming YangMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Anne F McGettrickSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-6887-7229
Maureen YinSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-1451-9906
Erica N MontanoDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Lihong HuoDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Juliana E Toller-KawahisaSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Vincent ZecchiniMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Tristram A J RyanSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-0278-1878
Alfonso Bolado-CarrancioEdinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-2330-7489
Alva M CaseyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7242-3251
Hiran A PragMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4753-8567
Ana S H CostaMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Gabriela De Los SantosDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mariko IshimoriDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel J WallaceDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Swamy VenuturupalliDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Efterpi NikitopoulouMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Norma FrizzellSchool of Medicine, University of South Carolina, Columbia, SC, USA.ORCID 0000-0002-5080-4176
Cecilia JohanssonNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-6607-5000
Alexander Von KriegsheimEdinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4952-8573
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1115-9618
Caroline JefferiesDivision of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Christian FrezzaMRC Cancer Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3293-7397
Luke A J O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. laoneill@tcd.ie.ORCID 0000-0002-4333-2748
Cedars-Sinai Medical Center · USTrinity College Dublin · IEUniversity of Cambridge · GBEdinburgh Cancer Research · GBUniversity of Cologne · DEImperial College London · GBTrinity College · CAUniversidade de São Paulo · BRUniversity of South Carolina · US
Funding
Sex and gender differences in lupus - intersection between immunometabolism, epigenetic remodeling and cardiac involvementR01AI164504 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JEFFERIES, CAROLINE · 2021 to 2024
$2.3MInvestigating Citric Acid Cycle Perturbations in Complex I Deficient Mitochondrial EncephalopathyR01NS126851 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIZZELL, NORMA · 2022 to 2025
$1.5MMedical Research Council MC_UU_00015/3Medical Research Council MC_UU_12022/6Medical Research Council MR/V000659/1NIAID NIH HHS R01 AI164504NINDS NIH HHS R01 NS126851Wellcome Trust
Abstract
Metabolic rewiring underlies the effector functions of macrophages
Indexed as
Fumarate HydrataseInterferon-betaMacrophagesMitochondriaRNA, MitochondrialArgininosuccinate SynthaseArgininosuccinic AcidAspartic AcidCell RespirationCytosolDEAD Box Protein 58FumaratesHumansInterferon-Induced Helicase, IFIH1LipopolysaccharidesLupus Erythematosus, SystemicArgininosuccinate SynthaseArgininosuccinic AcidAspartic AcidDEAD Box Protein 58Fumarate HydrataseFumaratesIFIH1 protein, humanInterferon-betaInterferon-Induced Helicase, IFIH1LipopolysaccharidesReceptors, ImmunologicRIGI protein, humanRNA, MitochondrialTLR7 protein, humanToll-Like Receptor 7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.