Evidence map›Paper›PMID 36890161›Full record

ArticleScientific reports2023

A significant, functional and replicable risk KTN1 variant block for schizophrenia.

Qiao Mao, Xiandong Lin, Qin Yin, Ping Liu, Yong Zhang, Shihao Qu, Jianying Xu, Wenhong Cheng, Xinqun Luo, Longli Kang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Phenome-wide association studies betweenFrontiers in psychiatry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 1 country.

Qiao Mao *Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, 618000, Sichuan, China.
Xiandong Lin *Laboratory of Radiation Oncology and Radiobiology, Fujian Provincial Cancer Hospital, the Teaching Hospital of Fujian Medical University, Fuzhou, 350014, Fujian, China.
Qin Yin *Department of Respiratory and Critical Care Medicine, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430000, Hubei, China.
Ping LiuDepartment of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, 618000, Sichuan, China.
Yong ZhangTianjin Mental Health Center, Tianjin, 300222, China.
Shihao QuZhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, 519001, China.
Jianying XuZhuhai Center for Maternal and Child Health Care, Zhuhai, Guangdong, 519001, China.
Wenhong ChengShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Xinqun LuoDepartment of Neurosurgery, The First Hospital, Fujian Medical University, Fuzhou, 350004, Fujian, China.
Longli KangKey Laboratory for Molecular Genetic Mechanisms and Intervention Research On High Altitude Diseases of Tibet Autonomous Region, Xizang Minzu University School of Medicine, Xiangyang, 712082, Shaanxi, China.
Reyisha TaximaimaitiDepartment of Neurology, Shanghai Tongren Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Chengchou ZhengMinqing Psychiatric Hospital, Minqing, 350800, Fujian, China.
Huihao ZhangThe First Affiliated Hospital, Fujian Medical University, Fuzhou, 350001, China.
Xiaoping WangDepartment of Neurology, The 1st People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, USA.
Honggang RenDepartment of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuping CaoDepartment of Psychiatry, Second Xiangya Hospital, Central South University, China National Clinical Research Center On Mental Disorders, China National Technology Institute On Mental Disorders, Changsha, 410011, Hunan, China. caoyp001@csu.edu.cn.
Jie LinFujian Center for Disease Control and Prevention, Fuzhou, 350012, Fujian, China. 108912906@qq.com.
Xingguang LuoBeijing Huilongguan Hospital, Peking University Huilongguan School of Clinical Medicine, Beijing, 100096, China. Xingguang.Luo@yale.edu.
Deyang Stomatological Hospital · CNFirst Affiliated Hospital of Fujian Medical University · CNWeihai Maternal and Child Health Hospital · CNFujian Institute of Microbiology · CNFujian Provincial Cancer Hospital · CNHuazhong University of Science and Technology · CNIntegrated Chinese Medicine (China) · CNPeking University · CNSecond Xiangya Hospital of Central South University · CNShanghai Jiao Tong University · CNShanghai Mental Health Center · CNTianjin Anding Hospital · CNXizang Minzu University · CN

Funding

MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0M
A Genome-Wide Association Study of SchizophreniaU01MH079469 · NIMH · NORTHSHORE UNIVERSITY HEALTHSYSTEM · PI GEJMAN, PABLO V. · 2007 to 2009
$4.4M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060879 · NIMH · WASHINGTON UNIVERSITY · PI CLONINGER, C. ROBERT · 1999 to 2006
$2.7M
Haplotype Mapping of Chromosome 5 Schizophrenia LocusR01MH071681 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI PURCELL, SHAUN M · 2006 to 2010
$2.6M
Software for the analysis of large-scale genotyping and sequencing studiesR01HG005827 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI PURCELL, SHAUN M · 2010 to 2016
$2.1M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059586 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SILVERMAN, JEREMY M. · 1999 to 2006
$1.9M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH061675 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI LEVINSON, DOUGLAS FREDERICK · 1999 to 2007
$1.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059587 · NIMH · EMORY UNIVERSITY · PI AMIN, FAROOQ · 1999 to 2006
$1.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059565 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FREEDMAN, ROBERT · 1999 to 2006
$1.7M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059588 · NIMH · UNIVERSITY OF QUEENSLAND · PI MOWRY, BRYAN JOHN · 1999 to 2006
$1.4M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH060870 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1999 to 2006
$1.3M
Genome-wide Association Study of SchizophreniaU01MH079470 · NIMH · STANFORD UNIVERSITY · PI LEVINSON, DOUGLAS FREDERICK · 2007 to 2009
$1.1M
Medical Research Council G0800509Medical Research Council G0801418Medical Research Council MR/P005748/1NHGRI NIH HHS R01 HG005827NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH071681NIMH NIH HHS R01 MH081800NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046289NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470Wellcome TrustWellcome Trust WT089062Wellcome Trust WT098051
6 · The paper itself

Abstract

Cortical and subcortical structural alteration has been extensively reported in schizophrenia, including the unusual expansion of gray matter volumes (GMVs) of basal ganglia (BG), especially putamen. Previous genome-wide association studies pinpointed kinectin 1 gene (KTN1) as the most significant gene regulating the GMV of putamen. In this study, the role of KTN1 variants in risk and pathogenesis of schizophrenia was explored. A dense set of SNPs (n = 849) covering entire KTN1 was analyzed in three independent European- or African-American samples (n = 6704) and one mixed European and Asian Psychiatric Genomics Consortium sample (n = 56,418 cases vs. 78,818 controls), to identify replicable SNP-schizophrenia associations. The regulatory effects of schizophrenia-associated variants on the KTN1 mRNA expression in 16 cortical or subcortical regions in two European cohorts (n = 138 and 210, respectively), the total intracranial volume (ICV) in 46 European cohorts (n = 18,713), the GMVs of seven subcortical structures in 50 European cohorts (n = 38,258), and the surface areas (SA) and thickness (TH) of whole cortex and 34 cortical regions in 50 European cohorts (n = 33,992) and eight non-European cohorts (n = 2944) were carefully explored. We found that across entire KTN1, only 26 SNPs within the same block (r

Indexed as

SchizophreniaBrainGenome-Wide Association StudyHumansMagnetic Resonance ImagingMembrane ProteinsPolymorphism, Single NucleotideRNA, MessengerKTN1 protein, humanMembrane ProteinsRNA, Messenger

Identifiers

PMID36890161
PMCPMC9995530
OpenAlexW4323652992

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