Evidence map›Paper›PMID 36889922›Full record

ArticleNeurology2023

Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study.

Robert P Murphy, Catriona Reddin, Annika Rosengren, Conor Judge, Graeme J Hankey, John Ferguson, Alberto Alvarez-Iglesias, Shahram Oveisgharan, Mohammad Wasay, Clodagh McDermott and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 4 countries.

Robert P MurphyFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom. robmurph8@hotmail.com.ORCID 0000-0001-5446-4175
Catriona ReddinFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0002-6396-5913
Annika RosengrenFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0002-5409-6605
Conor JudgeFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0001-9473-2920
Graeme J HankeyFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0002-6044-7328
John FergusonFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0001-8475-398X
Alberto Alvarez-IglesiasFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Shahram OveisgharanFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Mohammad WasayFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Clodagh McDermottFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Helle Klingenberg IversenFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Fernando LanasFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Fawaz Al-HussainFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Anna CzlonkowskaFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Aytekin OguzFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Adesola OgunniyiFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Albertino DamascenoFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.ORCID 0000-0003-0925-494X
Denis XavierFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Alvaro AvezumFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Xingyu WangFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Peter LanghorneFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Salim YusufFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
Martin O'DonnellFrom the HRB Clinical Research Facility Galway (R.P.M., C.R., C.J., J.F., A.A.-I., C.M., M.O.D.), School of Medicine, NUI Galway; Wellcome Trust-HRB (C.R., C.J.), Irish Clinical Academic Training, Galway, Ireland; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; Population Health Research Institute (C.J., S.Y., M.O.D.), Hamilton Health Sciences and McMaster University, Ontario, Canada; School of Medicine and Pharmacology (G.J.H.), The University of Western Australia, Perth, Washington; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Aga Khan University (M.W.), Karachi, Pakistan; Department of Neurology (H.K.I.), Rigshospitalet, University of Copenhagen; Health and Medical Sciences (H.K.I.), University of Copenhagen, Blegdamsvej 9, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (Aytekin Oguz), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Division of Cardiovascular Medicine (Adesola Ogunniyi), Department of Medicine, University College Hospital, Ibadan, Nigeria; Eduardo Mondlane University (A.D.), Maputo, Mozambique; St John's Medical College and Research Institute (D.X.), Bangalore, India; Instituto Dante Pazzanese de Cardiologia (A.A.), Sao Paulo, Brazil; Laboratory of Human Genetics (X.W.), Beijing Hypertension League Institute, China; and Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom.
INTERSTROKE investigators
Sahlgrenska University Hospital · SEOllscoil na Gaillimhe – University of Galway · IEUniversity of Copenhagen · DK

Funding

Wellcome Trust 203930/B/16/Z
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDepression has been reported to be a risk factor of acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke type.

methodsThe INTERSTROKE is an international case-control study of risk factors of first acute stroke, conducted in 32 countries. Cases were patients with CT- or MRI-confirmed incident acute hospitalized stroke, and controls were matched for age, sex, and within sites. Standardized questions asked about self-reported depressive symptoms during the previous 12 months and the use of prescribed antidepressant medications were recorded. Multivariable conditional logistic regression was used to determine the association of prestroke depressive symptoms with acute stroke risk. Adjusted ordinal logistic regression was used to explore the association of prestroke depressive symptoms with poststroke functional outcome, measured with the modified Rankin scale at 1 month after stroke.

resultsOf 26,877 participants, 40.4% were women, and the mean age was 61.7 ± 13.4 years. The prevalence of depressive symptoms within the last 12 months was higher in cases compared with that in controls (18.3% vs 14.1%, DISCUSSION: In this global study, we recorded that depressive symptoms are an important risk factor of acute stroke, including both ischemic and hemorrhagic stroke. Preadmission depressive symptoms were associated with poorer functional outcome, but not baseline stroke severity, suggesting an adverse role of depressive symptoms in poststroke recovery.

Indexed as

DepressionStrokeAgedCase-Control StudiesCerebral HemorrhageFemaleHumansMaleMiddle AgedRisk Factors

Identifiers

PMID36889922
PMCPMC10136021
OpenAlexW4323538929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.