Evidence map›Paper›PMID 36889832›Full record

ArticleBMJ open2023

Prospective observational study on the accuracy of predictors of high-grade atrioventricular conduction block after transcatheter aortic valve implantation (CONDUCT-TAVI): study protocol, background and significance.

Karan Rao, Kunwardeep Bhatia, Bernard Chan, Mitchell Cowan, Natasha Saad, Alexandra Baer, Hari Sritharan, Ingrid Bromhead, David Whalley, Usaid K Allahwala and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Karan RaoCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.ORCID 0000-0003-4689-9982
Kunwardeep BhatiaCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Bernard ChanCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Mitchell CowanCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Natasha SaadCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Alexandra BaerNorth Shore Private Hospital, Sydney, New South Wales, Australia.
Hari SritharanCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Ingrid BromheadCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
David WhalleyCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Usaid K AllahwalaCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Peter HansenCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Ravinay BhindiCardiology Department, Royal North Shore Hospital, St Leonards, New South Wales, Australia ravinay.bhindi@sydney.edu.au.
Royal North Shore Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAortic stenosis is the most common cardiac valve pathology worldwide and has a mortality rate of over 50% at 5 years if left untreated. Transcatheter aortic valve implantation (TAVI) is a minimally invasive and highly effective alternative treatment option to open-heart surgery. High-grade atrioventricular conduction block (HGAVB) is one of the most common complications after TAVI and requires a permanent pacemaker. Due to this, patients are typically monitored for 48 hours post TAVI, however up to 40% of HGAVB may delayed, and occur after discharge. Delayed HGAVB can cause syncope or sudden unexplained cardiac death in a vulnerable population, and no accurate methods currently exist to identify patients at risk. METHODS AND ANALYSIS: The prospective observational study on the accuracy of predictors of high-grade atrioventricular conduction block after transcatheter aortic valve implantation (CONDUCT-TAVI) trial is an Australian-led, multicentre, prospective observational study, aiming to improve the prediction of HGAVB, after TAVI. The primary objective of the trial is to assess whether published and novel invasive electrophysiology predictors performed immediately before and after TAVI can help predict HGAVB after TAVI. The secondary objective aims to further evaluate the accuracy of previously published predictors of HGAVB after TAVI, including CT measurements, 12-lead ECG, valve characteristics, percentage oversizing and implantation depth. Follow-up will be for 2 years, and detailed continuous heart rhythm monitoring will be obtained by inserting an implantable loop recorder in all participants. ETHICS AND DISSEMINATION: Ethics approval has been obtained for the two participating centres. Results of the study will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: ACTRN12621001700820.

Indexed as

Aortic Valve StenosisAtrioventricular BlockTranscatheter Aortic Valve ReplacementAustraliaHeartHumansObservational Studies as TopicTreatment OutcomeAdult cardiologyCARDIOLOGYValvular heart disease

Identifiers

PMID36889832
PMCPMC10008405
OpenAlexW4323544275

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.