Evidence map›Paper›PMID 36889566›Full record

ArticleEnvironmental research2023

Associations of urinary metabolite concentrations of phthalates and phthalate replacements with body composition from mid-childhood to early adolescence.

Lisa B Rokoff, Shravanthi M Seshasayee, Jenny L Carwile, Sheryl L Rifas-Shiman, Julianne Cook Botelho, Catherine M Gordon, Russ Hauser, Tamarra James-Todd, Jessica G Young, Clifford J Rosen and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Lisa B RokoffCenter for Interdisciplinary Population & Health Research, MaineHealth Institute for Research, Portland, ME, USA. Electronic address: Lisa.Rokoff@mainehealth.org.
Shravanthi M SeshasayeeCenter for Interdisciplinary Population & Health Research, MaineHealth Institute for Research, Portland, ME, USA.
Jenny L CarwileCenter for Interdisciplinary Population & Health Research, MaineHealth Institute for Research, Portland, ME, USA.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Julianne Cook BotelhoNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Catherine M GordonUSDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
Russ HauserDepartment of Environmental Health and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tamarra James-ToddDepartment of Environmental Health and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jessica G YoungDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Clifford J RosenCenter for Clinical and Translational Science, MaineHealth Institute for Research, Scarborough, ME, USA.
Antonia M CalafatNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Abby F FleischCenter for Interdisciplinary Population & Health Research, MaineHealth Institute for Research, Portland, ME, USA; Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA.
Harvard University · USMaineHealth · USCenters for Disease Control and Prevention · USChildren's Nutrition Research Center at Baylor College of Medicine · USMaine Medical Center · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Prospective associations of childhood PFAS with metabolomic profiles, pubertal timing, and bone healthR01ES030101 · NIEHS · MAINEHEALTH · PI Abby Fleisch · 2019 to 2026
$3.6M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD034568NIEHS NIH HHS R01 ES030101NIEHS NIH HHS R24 ES030894NIH HHS UH3 OD023286
6 · The paper itself

Abstract

backgroundPhthalates may adversely influence body composition by lowering anabolic hormones and activating peroxisome-proliferator activated receptor gamma. However, data are limited in adolescence when body mass distributions rapidly change and bone accrual peaks. Also, potential health effects of certain phthalate/replacements [e.g., di-2-ethylhexyl terephthalate (DEHTP)] have not been well studied.

methodsAmong 579 children in the Project Viva cohort, we used linear regression to evaluate associations of urinary concentrations of 19 phthalate/replacement metabolites from mid-childhood (median: 7.6 years; 2007-2010) with annualized change in areal bone mineral density (aBMD) and lean, total fat, and truncal fat mass as measured by dual-energy X-ray absorptiometry between mid-childhood and early adolescence (median: 12.8 years). We used quantile g-computation to assess associations of the overall chemical mixture with body composition. We adjusted for sociodemographics and tested for sex-specific associations.

resultsUrinary concentrations were highest for mono-2-ethyl-5-carboxypentyl phthalate [median (IQR): 46.7 (69.1) ng/mL]. We detected metabolites of most replacement phthalates in a relatively small number of participants [e.g., 28% for mono-2-ethyl-5-hydrohexyl terephthalate (MEHHTP; metabolite of DEHTP)]. Detectable (vs. non-detectable) MEHHTP was associated with less bone and greater fat accrual in males and greater bone and lean mass accrual in females [e.g., change in aBMD Z-score/year (95% CI): -0.049 (-0.085, -0.013) in males versus 0.042 (0.007, 0.076) in females; p

conclusionsConcentrations of select phthalate/replacement metabolites in mid-childhood were associated with changes in body composition through early adolescence. As use of phthalate replacements such as DEHTP may be increasing, further investigation can help better understand the potential effects of early-life exposures.

Indexed as

Environmental PollutantsPhthalic AcidsAdolescentBody CompositionBone DensityChildEnvironmental ExposureFemaleHumansMaleEnvironmental Pollutantsphthalic acidPhthalic Acidsterephthalic acidBody compositionChildrenEnvironmental exposurePhthalate replacementsPhthalates

Identifiers

PMID36889566
PMCPMC10101932
OpenAlexW4323307344

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.