Evidence map›Paper›PMID 36889531›Full record

ArticleAmerican journal of preventive medicine2023

The Role of BMI in Allostatic Load and Risk of Cancer Death.

Sydney E Andrzejak, Marquita W Lewis-Thames, Marvin E Langston, Yunan Han, Saira Khan, Darryl A Nettles, Lindsay N Fuzzell, Martha S Tingen, Justin X Moore

Abstract read
In one paragraph

Article in American journal of preventive medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sydney E AndrzejakCancer Prevention, Control & Population Health, Medical College of Georgia, Georgia Cancer Center, Augusta University, Augusta, Georgia.
Marquita W Lewis-ThamesDepartment of Medical Social Science, Center for Community Health, Feinberg School of Medicine, Northwestern University, Chicago, Ilinois.
Marvin E LangstonDepartment of Epidemiology & Population Health, Stanford University, Stanford, California.
Yunan HanDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Saira KhanDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Darryl A NettlesCancer Prevention, Control & Population Health, Medical College of Georgia, Georgia Cancer Center, Augusta University, Augusta, Georgia.
Lindsay N FuzzellDepartment of Health Outcomes & Behavior, H. Lee Moffitt Cancer Center, Tampa, Florida.
Martha S TingenCancer Prevention, Control & Population Health, Medical College of Georgia, Georgia Cancer Center, Augusta University, Augusta, Georgia.
Justin X MooreCancer Prevention, Control & Population Health, Medical College of Georgia, Georgia Cancer Center, Augusta University, Augusta, Georgia; Institute of Preventive and Public Health, Medical College of Georgia, Augusta University, Augusta, Georgia. Electronic address: jusmoore@augusta.edu.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
The Claude D. Pepper Older Americans Independence Center (OAIC) at Northwestern UniversityP30AG059988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CELLA, DAVID · 2020 to 2024
$7.1M
Improving adherence to posttreatment follow-up care for rural lung cancer survivors through a community-clinical survivorship care team modelK01CA262342 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEWIS, MARQUITA W. · 2021 to 2025
$801k
Geographic and Racial Disparities in Mammography Screening and Barriers to Receiving CareK01MD015304 · NIMHD · UNIVERSITY OF KENTUCKY · PI MOORE, JUSTIN XAVIER · 2020 to 2024
$646k
Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment.K01DK129405 · NIDDK · STANFORD UNIVERSITY · PI LANGSTON, MARVIN EPOLIAN · 2021 to 2024
$616k
NCATS NIH HHS UL1 TR001422NCI NIH HHS K01 CA262342NIA NIH HHS P30 AG059988NIDDK NIH HHS K01 DK129405NIMHD NIH HHS K01 MD015304NIMHD NIH HHS L60 MD016453
6 · The paper itself

Abstract

introductionObesity and proinflammatory conditions are associated with increased risks of cancer. The associations of baseline allostatic load with cancer mortality and whether this association is modified by body mass index (BMI) were examined.

methodsA retrospective analysis was performed in March-September 2022 using National Health and Nutrition Examination Survey years 1988 through 2010 linked with the National Death Index through December 31, 2019. Fine and Gray Cox proportional hazard models were stratified by BMI status to estimate subdistribution hazard ratios of cancer death between high and low allostatic load status (adjusted for age, sociodemographics, and health factors).

resultsIn fully adjusted models, high allostatic load was associated with a 23% increased risk of cancer death (adjusted subdistribution hazard ratio=1.23; 95% CI=1.06, 1.43) among all participants, a 3% increased risk of cancer death (adjusted subdistribution hazard ratio=1.03; 95% CI=0.78, 1.34) among underweight/healthy weight adults, a 31% increased risk of cancer death (adjusted subdistribution hazard ratio=1.31; 95% CI=1.02, 1.67) among overweight adults, and a 39% increased risk of death (adjusted subdistribution hazard ratio=1.39; 95% CI=1.04, 1.88) among obese adults, when compared to those with low allostatic load.

conclusionsThe risk of cancer death is highest among those with high allostatic load and obese BMI, but this effect was attenuated among those with high allostatic load and underweight/healthy or overweight BMI.

Indexed as

AllostasisNeoplasmsAdultBody Mass IndexHumansNutrition SurveysObesityOverweightRetrospective StudiesRisk FactorsThinness

Identifiers

PMID36889531
PMCPMC10440242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.