Evidence map›Paper›PMID 36889318›Full record

ArticleCurrent biology : CB2023

Mouse spontaneous behavior reflects individual variation rather than estrous state.

Dana Rubi Levy, Nigel Hunter, Sherry Lin, Emma Marie Robinson, Winthrop Gillis, Eli Benjamin Conlin, Rockwell Anyoha, Rebecca M Shansky, Sandeep Robert Datta

Abstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  6. Article
  7. Review
  8. Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  13. Review
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Dana Rubi LevyDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Nigel HunterDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sherry LinDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Emma Marie RobinsonDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Winthrop GillisDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Eli Benjamin ConlinDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Rockwell AnyohaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Rebecca M ShanskyDepartment of Psychology, Northeastern University, Boston, MA, USA. Electronic address: r.shansky@northeastern.edu.
Sandeep Robert DattaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: srdatta@hms.harvard.edu.

Funding

Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI UCHIDA, NAOSHIGE · 2019 to 2023
$18.7M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8M
Infralimbic circuit control over a sex-dependent switch in threat responding.R01MH123803 · NIMH · NORTHEASTERN UNIVERSITY · PI REBECCA M SHANSKY · 2020 to 2026
$3.1M
CounterAct Administrative Supplement to NS114020 Automated Phenotyping in EpilepsyR01NS114020 · NINDS · STANFORD UNIVERSITY · PI DATTA, SANDEEP R, SOLTESZ, IVAN · 2019 to 2023
$2.3M
Neurobehavioral phenotyping of AD model mice using Motion SequencingRF1AG073625 · NIA · HARVARD MEDICAL SCHOOL · PI DATTA, SANDEEP R · 2021 to 2021
$1.9M
Mapping mesocortical contributions to estrous-dependent learning processesR21MH120546 · NIMH · NORTHEASTERN UNIVERSITY · PI SHANSKY, REBECCA M · 2019 to 2020
$592k
NIA NIH HHS RF1 AG073625NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH123803NIMH NIH HHS R21 MH120546NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS114020NINDS NIH HHS U19 NS113201
6 · The paper itself

Abstract

Behavior is shaped by both the internal state of an animal and its individual behavioral biases. Rhythmic variation in gonadal hormones during the estrous cycle is a defining feature of the female internal state, one that regulates many aspects of sociosexual behavior. However, it remains unclear whether estrous state influences spontaneous behavior and, if so, how these effects might relate to individual behavioral variation. Here, we address this question by longitudinally characterizing the open-field behavior of female mice across different phases of the estrous cycle, using unsupervised machine learning to decompose spontaneous behavior into its constituent elements.

Indexed as

Estrous CycleExploratory BehaviorAnimalsFemaleMaleMiceMovementbehaviorcomputational ethologyestrousexplorationindividualitymousesex differencesspontaneousvariability

Identifiers

PMID36889318
PMCPMC10090034

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.