ArticleBrazilian dental journal
Physicochemical properties, cytotoxicity and bioactivity of a ready-to-use bioceramic repair material.
Article in Brazilian dental journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of dentin pre-treatment with Bioglass F18 suspensions on surface characteristics and bond strength of endodontic sealers.Clinical oral investigations · 2026Article
- Comparison of Sealing Ability of Biodentine, Biostructure Mineral Trioxide Aggregate, Theracal LC, and Bio-C Repair as Perforation Repair Material: An Inverted Laser Scanning Confocal Microscopic Study.International journal of clinical pediatric dentistry · 2026Article
- Fracture resistance of maxillary central incisor with external cervical resorption restored with biomimetic bilayered restoration technique: AnJournal of conservative dentistry and endodontics · 2026Article
- A comparative evaluation of apical sealing ability of NeoPutty, Biodentine, and Bio-c repair using a radioactive isotope method - AnJournal of conservative dentistry and endodontics · 2026Article
- Modified Formulations of Silicate-Based Cements: Comparative Study of Physicochemical Properties.Materials (Basel, Switzerland) · 2026Article
- Evaluation of the Physicochemical and Biological Properties of Calcium-Silicate-Based Root-End Filling Materials.Journal of functional biomaterials · 2026Article
- Management of an Oblique Cervical Root Fracture in an Immature Maxillary Central Incisor: A Case Report.Case reports in dentistry · 2026Article
- Physical and surface analysis of calcium silicate Clinker after acid challenge: a micro-CT and SEM study.Brazilian oral research · 2026Article
- Sealing ability of nano-bioactive glass, Bio-C repair, and EndoSequence Bioceramic-root Repair Material putty as root end restoratives: A confocal laser microscopic study.Journal of conservative dentistry and endodontics · 2026Article
- Physicochemical evaluation of mineral trioxide aggregate and five mineral oxides calcium silicate-based cements.BMC oral health · 2025Article
- Biocompatibility and Bioactivity Evaluation of Novel Calcium Silicate-Based Sealer: In Vitro Study on Human Dental Pulp Stem Cells.European journal of dentistry · 2025Article
- AnJournal of conservative dentistry and endodontics · 2025Article
- In vitro Analysis of DSPP and BSP Expression: Comparing the Odontogenic Influence of Bio-C Repair and Biodentine in hDPSCs.European journal of dentistry · 2025Article
- Effect of blood and artificial saliva contamination on marginal adaptation and sealing ability of different retrograde filling materials: A comparative analysis.Journal of conservative dentistry and endodontics · 2024Article
- Cell Biological and Antibacterial Evaluation of a New Approach to Zirconia Implant Surfaces Modified with MTA.Biomimetics (Basel, Switzerland) · 2024Article
- Effect of pH on the solubility and volumetric change of ready-to-use Bio-C Repair bioceramic material.Brazilian oral research · 2024Article
- In vivo method to evaluate volumetric changes in bioceramic repair materials.Brazilian dental journal · 2024Article
- Comparative biological properties of resin-free and resin-based calcium silicate-based endodontic repair materials on human periodontal ligament stem cells.Clinical oral investigations · 2023Article
- The Effects of Tricalcium-Silicate-Nanoparticle-Containing Cement: In Vitro and In Vivo Studies.Materials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the physicochemical properties, cytotoxicity and bioactivity of a ready-to-use bioceramic material, Bio-C Repair (Angelus), in comparison with White MTA (Angelus) and Biodentine (Septodont). The physicochemical properties of setting time, radiopacity, pH, solubility, dimensional and volumetric changes were evaluated. Biocompatibility and bioactivity were assessed in Saos-2 osteoblast cell cultures by the MTT assay 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), Neutral Red (NR), Alizarin Red (ARS), and cell migration tests. Statistical analysis was performed by ANOVA, Tukey or Bonferroni tests (α = 0.05). Bio-C Repair had the longest setting time (p < 0.05), but radiopacity and solubility were accordance with the ISO 6876/2012 standards, besides linear expansion. Bio-C Repair and MTA had similar volumetric change (p > 0.05); lower than Biodentine (p < 0.05). All the materials evaluated had an alkaline pH. Bio-C Repair was cytocompatible and promoted mineralized nodule deposition in 21 days and cell migration in 3 days. In conclusion, Bio-C Repair had adequate radiopacity above 3mm Al, solubility less than 3%, dimensional expansion, and low volumetric change. In addition, Bio-C Repair promoted an alkaline pH and presented bioactivity and biocompatibility similar to MTA and Biodentine, showing potential for use as a repair material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.