ReviewBrazilian dental journal
Mechanism of action of Bioactive Endodontic Materials.
Review in Brazilian dental journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Premixed calcium silicate-based materials for pulpotomy outcomes in permanent and deciduous teeth: a systematic review and meta-analysis of clinical trials.Clinical oral investigations · 2025Pooled it
- Antibacterial activity of biodentine againstFrontiers in dental medicine · 2024Pooled it
- Apatite-like calcium phosphate deposition and physicochemical properties of an aspartic acid-functionalized hydraulic cement.Clinical oral investigations · 2026Article
- Article
- Comparative Evaluation of Polymeric and Metal Ultrasonic Tips for the Removal of Calcium Hydroxide From Root Canals.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Effects of sodium hypochlorite and chlorhexidine on microhardness and solubility of mineral trioxide aggregate and bioceramic putty.Journal of conservative dentistry and endodontics · 2026Article
- Bioactivity and dimensional stability of resin-, hybrid-, and silicate-based endodontic sealers: An in vitro comparative study.Journal of clinical and experimental dentistry · 2026Review
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Assessment of sealing ability, antibacterial effect and marginal adaptation of bioactive materials in pulpotomized primary molars: an in-vitro study.BMC oral health · 2026Article
- Comparative finite element analysis of internal root resorption treatment using various root canal filling materials.BMC oral health · 2026Article
- Root Canal Filling of Teeth with Open Apex Using Different Techniques, Low-Temperature Gutta-Percha Points, and Bioceramic Sealers.Brazilian dental journal · 2026Article
- Comparative Biocompatibility of Portland-Based Endodontic Cements Containing Niobium and/or Bismuth Oxides in Rat Subcutaneous Tissue.BioMed research international · 2026Article
- In vivo long-term effects of bioactive mineral trioxide aggregate on the inflammatory response and repair in dental pulp.Brazilian oral research · 2026Article
- Marginal Adaptability of Harvard MTA and Biodentine Used as Root-End Filling Material: A Comparative SEM Study.Materials (Basel, Switzerland) · 2025Article
- Physicochemical evaluation of mineral trioxide aggregate and five mineral oxides calcium silicate-based cements.BMC oral health · 2025Article
- Biocompatibility and Bioactivity Evaluation of Novel Calcium Silicate-Based Sealer: In Vitro Study on Human Dental Pulp Stem Cells.European journal of dentistry · 2025Article
- The Effect of Different pH and Temperature Values on CaPolymers · 2025Article
- Bio-obturation: A Novel Approach in Root Canal Treatment Using Endodontic Biomaterials.Iranian endodontic journal · 2025Article
- Review
- Influence of melatonin supplementation on tissue response of endodontic sealers in Wistar rats.Odontology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A continuous search for bioactive materials capable of supporting the replacement of damaged pulp tissue, with effective sealing potential and biocompatibility, has represented the attention of studies over the last decades. This study involves a narrative review of the literature developed by searching representative research in PUBMED/MEDLINE and searches in textbooks associated with the mechanism of action of bioactive materials (calcium hydroxide, mineral trioxide aggregate (MTA), and calcium silicate cements). The reflective analysis of the particularities of the chemical elements of these materials, considering the tissue and antibacterial mechanism of action, allows a better understanding of the characteristics and similarities in their tissue responses. Calcium hydroxide paste remains the antibacterial substance of choice as intracanal dressing for the treatment of root canal system infections. Calcium silicate cements, including MTA, show a favorable biological response with the stimulation of mineralized tissue deposition in sealed areas when in contact with connective tissue. This is due to the similarity between the chemical elements, especially ionic dissociation, the potential stimulation of enzymes in tissues, and the contribution towards an alkaline environment due to the pH of these materials. The behavior of bioactive materials, especially MTA and the new calcium silicate cements in the biological sealing activity, has been shown to be effective. Contemporary endodontics has access to bioactive materials with similar properties, which can stimulate a biological seal in lateral and furcation root perforations, root-end fillings and root fillings, pulp capping, pulpotomy, apexification, and regenerative endodontic procedures, in addition to other clinical conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.