Evidence map›Paper›PMID 36888695›Full record

ArticleScience translational medicine2023

Immature natural killer cells promote progression of triple-negative breast cancer.

Gatha Thacker, Samantha Henry, Ajeya Nandi, Rahul Debnath, Snahlata Singh, Anupma Nayak, Barbara Susnik, Melinda M Boone, Qing Zhang, Susan B Kesmodel and 5 more

Abstract read
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The immunology of human breast cancer.Nature reviews. Immunology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. NK Cell Activation by Platinum Boosts Immunotherapy in HRAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gatha ThackerDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6378-4442
Samantha HenryCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Ajeya NandiDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rahul DebnathDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5910-3993
Snahlata SinghDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Anupma NayakDepartment of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-7445-1897
Barbara SusnikDepartment of Pathology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-9649-4911
Melinda M BooneSylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-3463-4688
Qing ZhangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-6595-8995
Susan B KesmodelDeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-0010-6078
Sanjeev GumberDepartment of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Gokul M DasDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.ORCID 0000-0003-2937-8093
Taku KambayashiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Camila O Dos SantosCold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-3999-9523
Rumela ChakrabartiDepartment of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2124-8737

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Probing the role of epigenomics in Brca1-deficient mammary tumors.R01CA248158 · NCI · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$2.2M
Deciphering the function of DNp63 and MDSCs in tumor promotion and metastasis of TNBCsR01CA237243 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHAKRABARTI, RUMELA · 2019 to 2023
$1.8M
Defining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiationR01AG069727 · NIA · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$1.8M
NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA237243NCI NIH HHS R01 CA248158NIA NIH HHS R01 AG069727
6 · The paper itself

Abstract

Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor microenvironment and are generally considered to be antitumorigenic. Using single-cell RNA sequencing and functional analysis of multiple triple-negative breast cancer (TNBC) and basal tumor samples, we observed a unique subcluster of Socs3

Indexed as

Antineoplastic AgentsTriple Negative Breast NeoplasmsAnimalsB7-H1 AntigenHumansKiller Cells, NaturalMiceTumor MicroenvironmentAntineoplastic AgentsB7-H1 Antigen

Identifiers

PMID36888695
PMCPMC10875969

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.